ArticleThe Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation2007
Assist devices fail to reverse patterns of fetal gene expression despite beta-blockers.
Article in The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Electronic and regular cigarettes induce transcriptional and physiological changes in cardiomyocytes.BMC cardiovascular disorders · 2025Article
- The Role of Oncostatin M and Its Receptor Complexes in Cardiomyocyte Protection, Regeneration, and Failure.International journal of molecular sciences · 2022Review
- Electronic cigarette extract induced toxic effect in iPS-derived cardiomyocytes.BMC cardiovascular disorders · 2020Article
- Article
- DNA methylation reprograms cardiac metabolic gene expression in end-stage human heart failure.American journal of physiology. Heart and circulatory physiology · 2019Article
- Right ventricular involution: What can we learn from nature's model of compensated hypertrophy?The Journal of thoracic and cardiovascular surgery · 2018Article
- Hypoxia favors myosin heavy chain beta gene expression in an Hif-1alpha-dependent manner.Oncotarget · 2017Article
- Left ventricular assist device-induced reverse remodeling: it's not just about myocardial recovery.Expert review of medical devices · 2017Review
- Targeted myocardial gene expression in failing hearts by RNA sequencing.Journal of translational medicine · 2016Article
- The role of notch in the cardiovascular system: potential adverse effects of investigational notch inhibitors.Frontiers in oncology · 2014Review
- Is myocardial recovery possible and how do you measure it?Current cardiology reports · 2012Review
- β-myosin heavy chain is induced by pressure overload in a minor subpopulation of smaller mouse cardiac myocytes.Circulation research · 2011Article
- Reverse remodeling with left ventricular assist devices: a review of clinical, cellular, and molecular effects.Circulation. Heart failure · 2011Review
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
Abstract
backgroundHeart failure is associated with reversal to a fetal gene expression pattern of contractile and metabolic genes. Substantial recovery of ventricular function with assist devices is rare. Our goal was to evaluate the effects of assist devices on fetal gene expression and hypoxia inducible factor-1 alpha (HIF-1 alpha), a transcriptional factor in hypoxic signaling.
methodsHuman heart tissue was obtained from the left ventricular apex at the time of assist device implantation and again from the left ventricular free wall during cardiac transplantation. Non-failing tissue was obtained from unused hearts from human donors. Gene expression was measured with the Affymetrix 133 plus 2 Array. HIF-1 alpha was measured by Western blotting with commercially available antibodies.
resultsHeart failure was associated with a decrease in alpha-myosin heavy chain and sarcoplasmic reticulum-Ca(2+) adenosine triphosphatase messenger RNA expression along with an increase in skeletal tropomyosin. This pattern persisted after assist device therapy. Heart failure was also associated with abnormalities in regulatory metabolic genes including glucose transporter 1 (GLUT1). These patterns also persisted after assist device therapy despite a reduction in atrial natriuretic peptide expression and normalization of HIF-1 alpha.
conclusionsFailure of assist devices to produce sustained recovery of myocardial contractile function may be due in part to persistent fetal transcriptional patterns of contractile and metabolic genes.
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