ArticleBMC neuroscience2007
Identification of novel light-induced genes in the suprachiasmatic nucleus.
Article in BMC neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Meta-analysis of transcriptomic datasets identifies genes enriched in the mammalian circadian pacemaker.Nucleic acids research · 2017Pooled it
- Mining for novel candidate clock genes in the circadian regulatory network.BMC systems biology · 2015Pooled it
- Timed exercise stabilizes behavioral rhythms but not molecular programs in the brain's suprachiasmatic clock.iScience · 2023Article
- Analyses of circRNA Expression throughout the Light-Dark Cycle Reveal a Strong Regulation ofInternational journal of molecular sciences · 2022Article
- NPAS4 regulates the transcriptional response of the suprachiasmatic nucleus to light and circadian behavior.Neuron · 2021Article
- A Role for the Adenosine ADORA2B Receptor in Midazolam Induced Cognitive Dysfunction.Current pharmaceutical design · 2020Article
- Circadian clock genes and the transcriptional architecture of the clock mechanism.Journal of molecular endocrinology · 2019Review
- The molecular clock in the skin, its functionality, and how it is disrupted in cutaneous melanoma: a new pharmacological target?Cellular and molecular life sciences : CMLS · 2019Review
- Vasoactive intestinal peptide controls the suprachiasmatic circadian clock network via ERK1/2 and DUSP4 signalling.Nature communications · 2019Article
- Mapping Molecular Datasets Back to the Brain Regions They are Extracted from: Remembering the Native Countries of Hypothalamic Expatriates and Refugees.Advances in neurobiology · 2018Article
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- A Consistent Definition of Phase Resetting Using Hilbert Transform.International scholarly research notices · 2017Article
- Sex differences in Gadd45b expression and methylation in the developing rodent amygdala.Brain research · 2016Article
- Single-Cell Transcriptional Analysis Reveals Novel Neuronal Phenotypes and Interaction Networks Involved in the Central Circadian Clock.Frontiers in neuroscience · 2016Article
- Identification and functional analysis of early gene expression induced by circadian light-resetting in Drosophila.BMC genomics · 2015Article
- Effect of light on global gene expression in the neuroglobin-deficient mouse retina.Biomedical reports · 2014Article
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- Uncovering the proteome response of the master circadian clock to light using an AutoProteome system.Molecular & cellular proteomics : MCP · 2011Article
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Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe transmission of information about the photic environment to the circadian clock involves a complex array of neurotransmitters, receptors, and second messenger systems. Exposure of an animal to light during the subjective night initiates rapid transcription of a number of immediate-early genes in the suprachiasmatic nucleus of the hypothalamus. Some of these genes have known roles in entraining the circadian clock, while others have unknown functions. Using laser capture microscopy, microarray analysis, and quantitative real-time PCR, we performed a comprehensive screen for changes in gene expression immediately following a 30 minute light pulse in suprachiasmatic nucleus of mice.
resultsThe results of the microarray screen successfully identified previously known light-induced genes as well as several novel genes that may be important in the circadian clock. Newly identified light-induced genes include early growth response 2, proviral integration site 3, growth-arrest and DNA-damage-inducible 45 beta, and TCDD-inducible poly(ADP-ribose) polymerase. Comparative analysis of promoter sequences revealed the presence of evolutionarily conserved CRE and associated TATA box elements in most of the light-induced genes, while other core clock genes generally lack this combination of promoter elements.
conclusionThe photic signalling cascade in the suprachiasmatic nucleus activates an array of immediate-early genes, most of which have unknown functions in the circadian clock. Detected evolutionary conservation of CRE and TATA box elements in promoters of light-induced genes suggest that the functional role of these elements has likely remained the same over evolutionary time across mammalian orders.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.