ArticleGenome biology2007
Regulatory module network of basic/helix-loop-helix transcription factors in mouse brain.
Article in Genome biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
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- Characterizing dynamic regulatory programs in mouse lung development and their potential association with tumourigenesis via miRNA-TF-mRNA circuits.BMC systems biology · 2013Article
- Reconstructing differentially co-expressed gene modules and regulatory networks of soybean cells.BMC genomics · 2012Article
- An integrative approach to infer regulation programs in a transcription regulatory module network.Journal of biomedicine & biotechnology · 2012Article
- Neurologic and ocular phenotype in Pitt-Hopkins syndrome and a zebrafish model.Human genetics · 2011Article
- Review
- Cloning and characterization of the 5'UTR of the rat anti-apoptotic Bcl-w gene.Biochemical and biophysical research communications · 2009Article
- Position dependent responses to discontinuities in the retinal determination network.Developmental biology · 2009Article
- Identification of a set of genes showing regionally enriched expression in the mouse brain.BMC neuroscience · 2008Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundThe basic/helix-loop-helix (bHLH) proteins are important components of the transcriptional regulatory network, controlling a variety of biological processes, especially the development of the central nervous system. Until now, reports describing the regulatory network of the bHLH transcription factor (TF) family have been scarce. In order to understand the regulatory mechanisms of bHLH TFs in mouse brain, we inferred their regulatory network from genome-wide gene expression profiles with the module networks method.
resultsA regulatory network comprising 15 important bHLH TFs and 153 target genes was constructed. The network was divided into 28 modules based on expression profiles. A regulatory-motif search shows the complexity and diversity of the network. In addition, 26 cooperative bHLH TF pairs were also detected in the network. This cooperation suggests possible physical interactions or genetic regulation between TFs. Interestingly, some TFs in the network regulate more than one module. A novel cross-repression between Neurod6 and Hey2 was identified, which may control various functions in different brain regions. The presence of TF binding sites (TFBSs) in the promoter regions of their target genes validates more than 70% of TF-target gene pairs of the network. Literature mining provides additional support for five modules. More importantly, the regulatory relationships among selected key components are all validated in mutant mice.
conclusionOur network is reliable and very informative for understanding the role of bHLH TFs in mouse brain development and function. It provides a framework for future experimental analyses.
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