ArticleBiochemistry2007
Alpha and beta chains of hemoglobin inhibit production of Staphylococcus aureus exotoxins.
Article in Biochemistry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 58 citations in OpenAlex.
- Antifungal, antibacterial, and anti-inflammatory activity of glycerol dithionomonolaurate, an analog of glycerol monolaurate.mSphere · 2025Article
- Prevalence of exotoxin and type III secretion system genes in multidrug-resistant Pseudomonas aeruginosa isolates from patients with burn injuries in Southern Iran.BMC infectious diseases · 2025Article
- Chemically diverse antimicrobial peptides induce hyperpolarization of the E. coli membrane.Communications biology · 2024Article
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- Device-Associated Menstrual Toxic Shock Syndrome.Clinical microbiology reviews · 2020Review
- The SrrAB two-component system regulatesProceedings of the National Academy of Sciences of the United States of America · 2020Article
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- Regulation ofMicrobiology spectrum · 2019Review
- Sub-inhibitory Effects of Antimicrobial Peptides.Frontiers in microbiology · 2019Review
- Molecular Typing and Variations in Amount ofFrontiers in microbiology · 2019Article
- Impact of Environmental Cues on Staphylococcal Quorum Sensing and Biofilm Development.The Journal of biological chemistry · 2016Review
- Staphylococcus aureus β-Toxin Mutants Are Defective in Biofilm Ligase and Sphingomyelinase Activity, and Causation of Infective Endocarditis and Sepsis.Biochemistry · 2016Article
- Novel Tissue Level Effects of the Staphylococcus aureus Enterotoxin Gene Cluster Are Essential for Infective Endocarditis.PloS one · 2016Article
- The effects of spatial structure, frequency dependence and resistance evolution on the dynamics of toxin-mediated microbial invasions.Evolutionary applications · 2015Article
- ω-Hydroxyemodin limits staphylococcus aureus quorum sensing-mediated pathogenesis and inflammation.Antimicrobial agents and chemotherapy · 2015Article
- Impact of the Regulators SigB, Rot, SarA and sarS on the Toxic Shock Tst Promoter and TSST-1 Expression in Staphylococcus aureus.PloS one · 2015Article
- Staphylococcus aureus β-toxin production is common in strains with the β-toxin gene inactivated by bacteriophage.The Journal of infectious diseases · 2014Article
- Staphylococcal superantigens interact with multiple host receptors to cause serious diseases.Immunologic research · 2014Review
- Novel antimicrobial peptides that inhibit gram positive bacterial exotoxin synthesis.PloS one · 2014Article
- Development of a mimotope vaccine targeting the Staphylococcus aureus quorum sensing pathway.PloS one · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
Prior studies suggest Staphylococcus aureus exotoxins are not produced when the organism is cultured in human blood. Human blood was fractionated into plasma and water-lysed red blood cells, and it was demonstrated that mixtures of alpha and beta globins of hemoglobin (as low as 1 mug/mL) inhibited S. aureus exotoxin production while increasing production of protein A and not affecting bacterial growth. Pepsin but not trypsin digestion destroyed the ability of alpha and beta globin to inhibit exotoxin production. Exotoxin production by both methicillin-resistant and methicillin-susceptible organisms was inhibited. Production of streptococcal pyrogenic exotoxin A by Streptococcus pyogenes was unaffected by alpha and beta globin chains but was inhibited when produced in S. aureus. Use of isogenic S. aureus strains suggested the targets of alpha and beta globin chains, leading to inhibition of staphylococcal exotoxins, included the two-component system SrrA-SrrB. delta hemolysin production was also inhibited, suggesting the two-component (and quorum sensing) system AgrA-AgrC was targeted. The alpha and beta globin chains represent promising molecules to interfere with the pathogenesis of serious staphylococcal diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.