ArticleThe Journal of infectious diseases2007
Spatially and genetically distinct African Trypanosome virulence variants defined by host interferon-gamma response.
Article in The Journal of infectious diseases, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- Prevalence and outcomes of malaria as co-infection among patients with human African trypanosomiasis: a systematic review and meta-analysis.Scientific reports · 2021Pooled it
- Unravelling human trypanotolerance: IL8 is associated with infection control whereas IL10 and TNFα are associated with subsequent disease development.PLoS pathogens · 2014Trial
- Pathogenicity and virulence of African trypanosomes: From laboratory models to clinically relevant hosts.Virulence · 2023Review
- Plasma cytokines quantification amongMalawi medical journal : the journal of Medical Association of Malawi · 2021Article
- Autoimmunity to phosphatidylserine and anemia in African Trypanosome infections.PLoS neglected tropical diseases · 2021Article
- Article
- Association of APOL1 renal disease risk alleles with Trypanosoma brucei rhodesiense infection outcomes in the northern part of Malawi.PLoS neglected tropical diseases · 2019Article
- Clinical and Neuropathogenetic Aspects of Human African Trypanosomiasis.Frontiers in immunology · 2019Review
- Plasma cytokine profiles associated withAllergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2019Article
- Salivarian Trypanosomosis: A Review of Parasites Involved, Their Global Distribution and Their Interaction With the Innate and Adaptive Mammalian Host Immune System.Frontiers in immunology · 2018Review
- Metabolic Profiling of Central Nervous System Disease in Trypanosoma brucei rhodesiense Infection.The Journal of infectious diseases · 2017Article
- Relationship between Trypanosoma brucei rhodesiense genetic diversity and clinical spectrum among sleeping sickness patients in Uganda.BMC research notes · 2017Article
- A polymorphism in the haptoglobin, haptoglobin related protein locus is associated with risk of human sleeping sickness within Cameroonian populations.PLoS neglected tropical diseases · 2017Article
- The relationship of endotoxaemia to peripheral and central nervous system inflammatory responses in Human African Trypanosomiasis.Parasitology · 2017Article
- Kynurenine Pathway Activation in Human African Trypanosomiasis.The Journal of infectious diseases · 2017Article
- Population genetic structure and temporal stability among Trypanosoma brucei rhodesiense isolates in Uganda.Parasites & vectors · 2016Article
- An Overview ofFrontiers in microbiology · 2016Review
- The role of cytokines in the pathogenesis and staging of Trypanosoma brucei rhodesiense sleeping sickness.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2016Review
- Interleukin (IL)-6 and IL-10 Are Up Regulated in Late Stage Trypanosoma brucei rhodesiense Sleeping Sickness.PLoS neglected tropical diseases · 2015Article
- Genetic diversity and population structure of Trypanosoma brucei in Uganda: implications for the epidemiology of sleeping sickness and Nagana.PLoS neglected tropical diseases · 2015Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
We describe 2 spatially distinct foci of human African trypanosomiasis in eastern Uganda. The Tororo and Soroti foci of Trypanosoma brucei rhodesiense infection were genetically distinct as characterized by 6 microsatellite and 1 minisatellite polymorphic markers and were characterized by differences in disease progression and host-immune response. In particular, infections with the Tororo genotype exhibited an increased frequency of progression to and severity of the meningoencephalitic stage and higher plasma interferon (IFN)- gamma concentration, compared with those with the Soroti genotype. We propose that the magnitude of the systemic IFN- gamma response determines the time at which infected individuals develop central nervous system infection and that this is consistent with the recently described role of IFN- gamma in facilitating blood-brain barrier transmigration of trypanosomes in an experimental model of infection. The identification of trypanosome isolates with differing disease progression phenotypes provides the first field-based genetic evidence for virulence variants in T. brucei rhodesiense.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.