Evidence map›Paper›PMID 18008168›Full record

ReviewBiotechnology letters2008

Exploiting cholera vaccines as a versatile antigen delivery platform.

Anisia J Silva, Francis O Eko, Jorge A Benitez

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biotechnology letters, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Live bacterial vaccine vectors: an overview.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2014
    Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Anisia J SilvaDepartment of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, 720 Westview Dr., SW Atlanta, GA 30310, USA. asilva-benitez@msm.edu
Francis O Eko
Jorge A Benitez
Morehouse School of Medicine · US

Funding

Vascular Cell Apoptosis: Mediator Role of Transforming Growth Factor-beta-1S06GM008248 · NIGMS · MOREHOUSE SCHOOL OF MEDICINE · PI SILVA, ANISIA J · 1989 to 2009
$19.8M
Regulation of Vibrio cholerae motility, stress response and detachment from intesSC1AI104993 · NIAID · MOREHOUSE SCHOOL OF MEDICINE · PI SILVA-BENITEZ, ANISIA J · 2012 to 2015
$1.3M
Regulation of the Vibrio cholerae intestinal exit planR21AI081039 · NIAID · MOREHOUSE SCHOOL OF MEDICINE · PI SILVA-BENITEZ, ANISIA J · 2009 to 2010
$385k
NIAID NIH HHS R21 AI081039NIAID NIH HHS SC1 AI104993NIGMS NIH HHS S06 GM008248
6 · The paper itself

Abstract

The development of safe, immunogenic and protective cholera vaccine candidates makes possible their use as a versatile antigen delivery platform. Foreign antigens can be delivered to the immune system with cholera vaccines by expressing heterologous antigens in live attenuated vectors, as fusion proteins with cholera toxin subunits combined with inactivated Vibrio cholerae whole cells or by exposing them on the surface of V. cholerae ghosts. Progress in our understanding of the genes expressed by V. cholerae during infection creates unprecedented opportunities to develop an improved generation of vaccine vectors to induce immune protection against a broad range of pathogenic organisms.

Indexed as

Antigens, BacterialCholeraCholera VaccinesVibrio choleraeAntigens, BacterialCholera Vaccines

Identifiers

PMID18008168
PMCPMC2753531
OpenAlexW2043517977

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.