ArticleDiabetologia2008
The GCKR rs780094 polymorphism is associated with elevated fasting serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of type 2 diabetes.
Article in Diabetologia, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 107 papers, 14 of them syntheses that pooled it.
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Who cites it
107 citing papers in PubMed, 14 syntheses or guidelines pooled it, 172 citations in OpenAlex.
- Association between Genotype and the Glycemic Response to an Oral Glucose Tolerance Test: A Systematic Review.Nutrients · 2023Pooled it
- Sex-specific and pleiotropic effects underlying kidney function identified from GWAS meta-analysis.Nature communications · 2019Pooled it
- Genetic polymorphisms associated with nonalcoholic fatty liver disease in Uyghur population: a case-control study and meta-analysis.Lipids in health and disease · 2019Pooled it
- Association of type 2 diabetes susceptible genes GCKR, SLC30A8, and FTO polymorphisms with gestational diabetes mellitus risk: a meta-analysis.Endocrine · 2018Pooled it
- Association of common gene variants in glucokinase regulatory protein with cardiorenal disease: A systematic review and meta-analysis.PloS one · 2018Pooled it
- Serum uric acid levels are associated with polymorphisms in the SLC2A9, SF1, and GCKR genes in a Chinese population.Acta pharmacologica Sinica · 2014Pooled it
- Analysis of metabolic syndrome components in >15 000 african americans identifies pleiotropic variants: results from the population architecture using genomics and epidemiology study.Circulation. Cardiovascular genetics · 2014Pooled it
- Association of glucokinase regulatory protein polymorphism with type 2 diabetes and fasting plasma glucose: a meta-analysis.Molecular biology reports · 2013Pooled it
- Pooled it
- Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits.Circulation. Cardiovascular genetics · 2012Pooled it
- Pooled it
- Association of genetic Loci with glucose levels in childhood and adolescence: a meta-analysis of over 6,000 children.Diabetes · 2011Pooled it
- Variants at DGKB/TMEM195, ADRA2A, GLIS3 and C2CD4B loci are associated with reduced glucose-stimulated beta cell function in middle-aged Danish people.Diabetologia · 2010Pooled it
- Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations.PLoS genetics · 2009Pooled it
- Relationship betweenWorld journal of diabetes · 2023Trial
- Effects of genetic variants previously associated with fasting glucose and insulin in the Diabetes Prevention Program.PloS one · 2012Trial
- Effects of MK-0941, a novel glucokinase activator, on glycemic control in insulin-treated patients with type 2 diabetes.Diabetes care · 2011 · on this mapTrial
- Triglyceride response to an intensive lifestyle intervention is enhanced in carriers of the GCKR Pro446Leu polymorphism.The Journal of clinical endocrinology and metabolism · 2011Trial
- Comparison of two-stage methods for count data in Mendelian randomization: a simulation study.Journal of comparative effectiveness research · 2026Article
- Unveiling Shared Genetic Architectures and Causality: Intestinal Diseases and Neurological Diseases.Brain and behavior · 2026Article
47 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
15 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisRecent genome-wide association studies have suggested that a polymorphism in GCKR, the gene encoding the glucokinase regulatory protein, is involved in triacylglycerol regulation. Our aim was to examine in large-scale studies the common GCKR rs780094 polymorphism in relation to metabolic traits (mainly fasting hypertriacylglycerolaemia) and traits related to pancreatic beta cell function.
methodsThe polymorphism was genotyped in 16,853 Danes using Taqman allelic discrimination. Association was analysed in case-control studies and quantitative trait analyses. We also analysed the possible interactive effect between the GCK -30G>A polymorphism and the GCKR rs780094 variant on metabolic traits.
resultsThe minor GCKR A-allele of rs780094 is associated with an increased level of fasting serum triacylglycerol (p = 6 x 10(-14)), impaired fasting (p = 0.001) and OGTT-related insulin release (p = 3 x 10(-6)), reduced homeostasis model assessment of insulin resistance (p = 0.0004), WHO-defined dyslipidaemia (p = 6 x 10(-9)) and a modestly decreased risk of type 2 diabetes (p = 0.01). Significantly increased fasting serum insulin concentrations were demonstrated when analysing the GCK -30A and GCKR rs780094 G-alleles in an additive model. CONCLUSIONS/
interpretationThe GCKR rs780094 polymorphism, or another variant with which it is in tight linkage disequilibrium, is likely to increase glucokinase regulatory protein activity to induce improved glycaemic regulation at the expense of hypertriacylglycerolaemia as reflected in the present study of 16,853 Danes. We also suggest an additive effect of GCK and GCKR risk alleles on [corrected] serum insulin release.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.