Evidence map›Paper›PMID 18008056›Full record

ReviewImmunologic research2008

Notch signaling in differentiation and function of dendritic cells.

Pingyan Cheng, Dmitry Gabrilovich

Abstract readReview
In one paragraph

Review in Immunologic research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Trial
  2. Structural-activity relationship ofFrontiers in immunology · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. γ-Secretase fanning the fire of innate immunity.Biochemical Society transactions · 2023
    Review
  8. Notch Signaling in Acute Inflammation and Sepsis.International journal of molecular sciences · 2023
    Review
  9. Article
  10. Notch signaling pathway in infectious diseases: role in the regulation of immune response.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2021
    Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Pingyan ChengH. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
Dmitry Gabrilovich

Funding

Correction of myeloid cell defects in cancerR01CA084488 · NCI · WISTAR INSTITUTE · PI GABRILOVICH, DMITRY I · 1999 to 2017
$5.4M
Mechanism of myeloid cell defect in cancerR01CA100062 · NCI · WISTAR INSTITUTE · PI GABRILOVICH, DMITRY I · 2004 to 2018
$4.0M
NCI NIH HHS R01 CA084488NCI NIH HHS R01 CA100062
6 · The paper itself

Abstract

Hematopoietic stem cells give rise to multiple lineages of cells. This process is governed by a tightly controlled signaling network regulated by cytokines and a direct cell-cell contact. Notch signaling represents one of the major pathways activated during direct interaction between hematopoietic progenitor cells and bone marrow stroma. A critical role of Notch signaling in differentiation of T- and B-lymphocytes has now been established. Until recently, the role of Notch signaling in the development of myeloid cells and particular dendritic cells remained unclear. In this review, we discuss recent exciting findings that shed light on the critical role of Notch in differentiation and the function of dendritic cells and its impact on immune responses.

Indexed as

Cell DifferentiationSignal TransductionAnimalsB-LymphocytesBone MarrowDendritic CellsHematopoietic Stem CellsHumansLymphocyte ActivationMiceNF-kappa BReceptors, NotchTh1 CellsTh2 CellsT-Lymphocytes, RegulatoryTranscriptional ActivationNF-kappa BReceptors, Notch

Identifiers

PMID18008056
PMCPMC2709100

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.