ArticleEnvironmental health perspectives2007
Using lymphocyte and plasma Hsp70 as biomarkers for assessing coke oven exposure among steel workers.
Article in Environmental health perspectives, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 54 citations in OpenAlex.
- Environmental stress and hypertension: the disregarded role of HSP70.Journal of human hypertension · 2024Review
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- Heat stress inhibits the proliferation and differentiation of myoblasts and is associated with damage to mitochondria.Frontiers in cell and developmental biology · 2023Article
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- Extracellular Heat Shock Proteins as Therapeutic Targets and Biomarkers in Fibrosing Interstitial Lung Diseases.International journal of molecular sciences · 2021Review
- Benchmark dose estimation for coke oven emissions based on oxidative damage in Chinese exposed workers.Ecotoxicology and environmental safety · 2020Article
- The role of NCell stress & chaperones · 2019Article
- Association between occupational heat stress and DNA damage in lymphocytes of workers exposed to hot working environments in a steel industry in Southern India.Temperature (Austin, Tex.) · 2019Article
- Subacute exposure to residual oil fly ash (ROFA) increases eHSP70 content and extracellular-to-intracellular HSP70 ratio: a relation with oxidative stress markers.Cell stress & chaperones · 2018Article
- Acute exercise boosts cell proliferation and the heat shock response in lymphocytes: correlation with cytokine production and extracellular-to-intracellular HSP70 ratio.Cell stress & chaperones · 2017Article
- Effects of coke oven emissions and benzo[a]pyrene on blood pressure and electrocardiogram in coke oven workers.Journal of occupational health · 2017Article
- Exercise Training under Exposure to Low Levels of Fine Particulate Matter: Effects on Heart Oxidative Stress and Extra-to-Intracellular HSP70 Ratio.Oxidative medicine and cellular longevity · 2017Article
- Coke workers' exposure to volatile organic compounds in northern China: a case study in Shanxi Province.Environmental monitoring and assessment · 2015Article
- Lymphocyte oxidative stress/genotoxic effects are related to serum IgG and IgA levels in coke oven workers.TheScientificWorldJournal · 2014Article
- Association of plasma IL-6 and Hsp70 with HRV at different levels of PAHs metabolites.PloS one · 2014Article
- Development of stable HSPA1A promoter-driven luciferase reporter HepG2 cells for assessing the toxicity of organic pollutants present in air.Cell stress & chaperones · 2012Article
- Short (GT) ( n ) repeats in heme oxygenase-1 gene promoter are associated with lower risk of coronary heart disease in subjects with high levels of oxidative stress.Cell stress & chaperones · 2012Article
- Article
- Malondialdehyde-deoxyguanosine adducts among workers of a Thai industrial estate and nearby residents.Environmental health perspectives · 2010Article
- The level of Hsp27 in lymphocytes is negatively associated with a higher risk of lung cancer.Cell stress & chaperones · 2009Article
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHsp70, an early-response protein induced when organisms are confronted with simple or complicated environmental stresses, can act as either a cellular protector or a danger signal.
objectivesThe goal of this study was to evaluate levels of lymphocyte and/or plasma Hsp70 as biomarkers for assessing exposure response to complex coke oven emissions (COEs).
methodsWe recruited 101 coke oven workers and determined levels of polycyclic aromatic hydrocarbon (PAH) exposure, urinary 1-hydroxypyrene (1-OHP), genotoxic damage by comet assay and micronuclei test, and other markers of damage, including plasma malondialdehyde (MDA) and lactate dehydrogenase (LDH). These were compared to levels of lymphocyte (intra-cellular) and plasma (extracellular) Hsp70 using Western blots and enzyme-linked immunosorbent assays (ELISA), respectively.
resultsWe observed a COEs-related dose-dependent increase in levels of DNA damage, micronuclei rate, MDA concentration, and LDH activity. Lymphocyte Hsp70 levels increased in the intermediate-exposure group (1.39 +/- 0.88) but decreased in the high-exposure group (1.10 +/- 0.55), compared with the low-exposure group. In contrast, plasma Hsp70 levels progressively increased as the dose of exposure increased. Negative correlations were seen between lymphocyte Hsp70 levels and olive tail moment and LDH activity in the intermediate- and high-exposure groups. However, we observed positive correlations between plasma Hsp70 levels and LDH activity in the low and intermediate groups.
conclusionsIn workers exposed to COEs, high lymphocyte Hsp70 levels may provide protection and high plasma Hsp70 levels may serve as a danger marker. Larger validation studies are needed to establish the utility of Hsp70 as a response marker.
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