ArticleEMBO reports2008
Saccharomyces cerevisiae Rad16 mediates ultraviolet-dependent histone H3 acetylation required for efficient global genome nucleotide-excision repair.
Article in EMBO reports, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 58 citations in OpenAlex.
- Photoreactivation Activities of Rad5, Rad16A and Rad16B HelpJournal of fungi (Basel, Switzerland) · 2024Article
- DNA Repair in Nucleosomes: Insights from Histone Modifications and Mutants.International journal of molecular sciences · 2024Review
- Article
- Snf2 Proteins Are Required to Generate Gamete Pronuclei inMicroorganisms · 2022Article
- Epigenetic Regulation of Nucleotide Excision Repair.Frontiers in cell and developmental biology · 2022Review
- Nucleosome remodeling at origins of global genome-nucleotide excision repair occurs at the boundaries of higher-order chromatin structure.Genome research · 2019Article
- Disruption of the transcription factors Thi2p and Nrm1p alleviates the post-glucose effect on xylose utilization inBiotechnology for biofuels · 2018Article
- ASH1L histone methyltransferase regulates the handoff between damage recognition factors in global-genome nucleotide excision repair.Nature communications · 2017Article
- Emerging roles for histone modifications in DNA excision repair.FEMS yeast research · 2016Review
- Facilitation of base excision repair by chromatin remodeling.DNA repair · 2015Review
- Sandcastle: software for revealing latent information in multiple experimental ChIP-chip datasets via a novel normalisation procedure.Scientific reports · 2015Article
- Chromatin modifications and DNA repair: beyond double-strand breaks.Frontiers in genetics · 2014Review
- Histone variant Htz1 promotes histone H3 acetylation to enhance nucleotide excision repair in Htz1 nucleosomes.Nucleic acids research · 2013Article
- Review
- Implication of posttranslational histone modifications in nucleotide excision repair.International journal of molecular sciences · 2012Review
- ATP-dependent chromatin remodeling in the DNA-damage response.Epigenetics & chromatin · 2012Article
- Nucleotide excision repair in cellular chromatin: studies with yeast from nucleotide to gene to genome.International journal of molecular sciences · 2012Review
- The emerging roles of ATP-dependent chromatin remodeling enzymes in nucleotide excision repair.International journal of molecular sciences · 2012Review
- Diverse roles of RNA polymerase II-associated factor 1 complex in different subpathways of nucleotide excision repair.The Journal of biological chemistry · 2011Article
- How chromatin is remodelled during DNA repair of UV-induced DNA damage in Saccharomyces cerevisiae.PLoS genetics · 2011Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
In yeast, global genome nucleotide-excision repair (GG-NER) requires a protein complex containing Rad7 and Rad16. Rad16 is a member of the switch/sucrose nonfermentable superfamily, and it is presumed that chromatin remodelling is its primary function during repair. We show that RAD16 is required for ultraviolet-dependent hyperacetylation of histone H3 (Lys 9 and Lys 14) at the MFA2 promoter and throughout the genome. The yeast repressor complex Ssn6-Tup1 represses many genes including MFA2. TUP1 deletion results in constitutive hyperacetylation of histone H3, nucleosome disruption and derepression of gene transcription in Tup1-regulated genes. GG-NER in the MFA2 promoter proceeds more rapidly in tup1Delta alpha-cells compared with wild type, even when transcription is inhibited. We show that elevated histone H3 acetylation levels in the MFA2 promoter in tup1Delta alpha-cells result in Rad7- and Rad16-independent GG-NER, and that Rad16 mediates the ultraviolet-induced acetylation of histone H3, necessary for efficient GG-NER.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.