ArticleToxicological sciences : an official journal of the Society of Toxicology2008
Aryl hydrocarbon receptor targets pathways extrinsic to bone marrow cells to enhance neutrophil recruitment during influenza virus infection.
Article in Toxicological sciences : an official journal of the Society of Toxicology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 42 citations in OpenAlex.
- The aryl hydrocarbon receptor: structure, signaling, physiology and pathology.Signal transduction and targeted therapy · 2026Review
- Timing influences the impact of aryl hydrocarbon receptor activation on the humoral immune response to respiratory viral infection.Toxicology and applied pharmacology · 2024Article
- Role of aryl hydrocarbon receptors in infection and inflammation.Frontiers in immunology · 2024Review
- Computational Approach to Link Chemicals in Anthropogenic Smoke Particulate Matter with Toxicity.Chemical research in toxicology · 2022Article
- The Aryl Hydrocarbon Receptor as a Modulator of Anti-viral Immunity.Frontiers in immunology · 2021Review
- Article
- Redox control in the pathophysiology of influenza virus infection.BMC microbiology · 2020Review
- Aryl hydrocarbon receptor signaling modulates antiviral immune responses: ligand metabolism rather than chemical source is the stronger predictor of outcome.Scientific reports · 2018Article
- Environmental cues received during development shape dendritic cell responses later in life.PloS one · 2018Article
- Editor's Highlight: Ah Receptor Activation Potentiates Neutrophil Chemoattractant (C-X-C Motif) Ligand 5 Expression in Keratinocytes and Skin.Toxicological sciences : an official journal of the Society of Toxicology · 2017Article
- A Role for Neutrophils in Viral Respiratory Disease.Frontiers in immunology · 2017Review
- Local Generation of Kynurenines Mediates Inhibition of Neutrophil Chemotaxis by Uropathogenic Escherichia coli.Infection and immunity · 2016Article
- Differential consequences of two distinct AhR ligands on innate and adaptive immune responses to influenza A virus.Toxicological sciences : an official journal of the Society of Toxicology · 2014Article
- Toward understanding the role of aryl hydrocarbon receptor in the immune system: current progress and future trends.BioMed research international · 2014Review
- Platelets from mice lacking the aryl hydrocarbon receptor exhibit defective collagen-dependent signaling.Journal of thrombosis and haemostasis : JTH · 2014Article
- New insights into the aryl hydrocarbon receptor as a modulator of host responses to infection.Seminars in immunopathology · 2013Review
- Novel cellular targets of AhR underlie alterations in neutrophilic inflammation and inducible nitric oxide synthase expression during influenza virus infection.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- A role of the aryl hydrocarbon receptor in attenuation of colitis.Digestive diseases and sciences · 2011Article
- The aryl hydrocarbon receptor: a perspective on potential roles in the immune system.Immunology · 2009Review
- The aryl hydrocarbon receptor is a modulator of anti-viral immunity.Biochemical pharmacology · 2009Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
There is growing evidence that neutrophils influence host resistance during influenza virus infection; however, factors that regulate neutrophil migration to the lung during viral infection are unclear. Activation of the aryl hydrocarbon receptor (AhR) by the pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD or dioxin) results in an increased number of neutrophils in the lung after influenza virus infection. The mechanism of AhR-mediated neutrophilia does not involve elevated levels of soluble neutrophil chemoattractants, upregulated adhesion molecules on pulmonary neutrophils, delayed neutrophil apoptosis, or increased vascular damage. In this study, we determined whether AhR activation increases neutrophil numbers systemically or only in the infected lung, and whether AhR-regulated events within the hematopoietic system underlie the dioxin-induced increase in pulmonary neutrophils observed during influenza virus infection. We report here that AhR activation does not increase neutrophil numbers systemically or increase neutrophil production in hematopoietic tissue, suggesting that the elevated number of neutrophils is restricted to the site of antigen challenge. The generation of CD45.2AhR-/--->CD45.1AhR+/+ bone marrow chimeric mice demonstrates that even when hematopoietic cells lack the AhR, TCDD treatment still results in twice as many pulmonary neutrophils compared with control-treated, infected CD45.2AhR-/--->CD45.1AhR+/+ chimeric mice. This finding reveals that AhR-mediated events extrinsic to bone marrow-derived cells affect the directional migration of neutrophils to the infected lung. These results suggest that the lung contains important and heretofore overlooked targets of AhR regulation, unveiling a novel mechanism for controlling neutrophil recruitment to the infected lung.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.