ArticleAmerican journal of respiratory and critical care medicine2008
Airway smooth muscle in bronchial tone, inflammation, and remodeling: basic knowledge to clinical relevance.
Article in American journal of respiratory and critical care medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 85 citations in OpenAlex.
- Advances in Molecular Research of Tracheobronchial Tree Aging: A Systematic Review.International journal of molecular sciences · 2025Pooled it
- Recent advances in bronchial thermoplasty for severe asthma: a narrative review.Annals of translational medicine · 2022Review
- Carbocistein improves airway remodeling in asthmatic mice.American journal of translational research · 2022Article
- Aging increases senescence, calcium signaling, and extracellular matrix deposition in human airway smooth muscle.PloS one · 2021Article
- Targeting Airway Smooth Muscle Hypertrophy in Asthma: An Approach Whose Time Has Come.Journal of asthma and allergy · 2021Review
- Dynamic airway constriction in rats: heterogeneity and response to deep inspiration.American journal of physiology. Lung cellular and molecular physiology · 2019Article
- Obesity increases airway smooth muscle responses to contractile agonists.American journal of physiology. Lung cellular and molecular physiology · 2018Article
- Imidazole-induced contractions in bovine tracheal smooth muscle are not dependent on the cAMP pathway.The Journal of veterinary medical science · 2018Article
- Eosinophilic and Noneosinophilic Asthma.American journal of respiratory and critical care medicine · 2018Review
- Transforming Growth Factor β1 Function in Airway Remodeling and Hyperresponsiveness. The Missing Link?American journal of respiratory cell and molecular biology · 2017Review
- Bronchial thermoplasty and the role of airway smooth muscle: are we on the right direction?Therapeutics and clinical risk management · 2017Review
- Viable EdnraMammalian genome : official journal of the International Mammalian Genome Society · 2016Article
- Glucocorticoid and TNF signaling converge at A20 (TNFAIP3) to repress airway smooth muscle cytokine expression.American journal of physiology. Lung cellular and molecular physiology · 2016Article
- Airway Remodeling in Chronic Obstructive Pulmonary Disease and Asthma: the Role of Matrix Metalloproteinase-9.Archivum immunologiae et therapiae experimentalis · 2016Review
- NOS1-derived nitric oxide promotes NF-κB transcriptional activity through inhibition of suppressor of cytokine signaling-1.The Journal of experimental medicine · 2015Article
- Airway Inflammation after Bronchial Thermoplasty for Severe Asthma.Annals of the American Thoracic Society · 2015Observational
- Immunobiology of the critical asthma syndrome.Clinical reviews in allergy & immunology · 2015Review
- Bronchial thermoplasty in asthma: current perspectives.Journal of asthma and allergy · 2015Review
- Vitamin D Modulates Expression of the Airway Smooth Muscle Transcriptome in Fatal Asthma.PloS one · 2015Article
- Critical review of bronchial thermoplasty: where should it fit into asthma therapy?Current allergy and asthma reports · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 7 institutions in 2 countries.
Funding
Abstract
Airway smooth muscle (ASM) plays a pivotal role in modulating bronchomotor tone but also orchestrates and perpetuates airway inflammation and remodeling. Despite substantial research, there remain important unanswered questions. In 2006, the National Heart, Lung, and Blood Institute sponsored a workshop to define new directions in ASM biology. Important questions concerning the key functions of ASM include the following: Does developmental dysregulation of ASM function promote airway disease, what key signaling pathways in ASM evoke airway hyperresponsiveness in vivo, do alterations in ASM mass affect excitation-contraction coupling, and can ASM modulate airway inflammation and remodeling in a physiologically relevant manner? This workshop identified critical issues in ASM biology to delineate areas for scientific investigation in the identification of new therapeutic and diagnostic approaches in asthma, chronic obstructive pulmonary disease, and cystic fibrosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.