ArticleEndocrinology2008
Adrenal gland tumorigenesis after gonadectomy in mice is a complex genetic trait driven by epistatic loci.
Article in Endocrinology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 50 citations in OpenAlex.
- Androgen Receptor Is Dispensable for X-Zone Regression in the Female Adrenal but Regulates Post-Partum Corticosterone Levels and Protects Cortex Integrity.Frontiers in endocrinology · 2020Article
- P53/Rb inhibition induces metastatic adrenocortical carcinomas in a preclinical transgenic model.Oncogene · 2017Article
- A novel FOXO1-mediated dedifferentiation blocking role for DKK3 in adrenocortical carcinogenesis.BMC cancer · 2017Article
- GLI1Molecular and cellular endocrinology · 2017Article
- GATA factors in endocrine neoplasia.Molecular and cellular endocrinology · 2016Review
- Mouse models of adrenocortical tumors.Molecular and cellular endocrinology · 2016Review
- Toying with fate: Redirecting the differentiation of adrenocortical progenitor cells into gonadal-like tissue.Molecular and cellular endocrinology · 2015Review
- Novel markers of gonadectomy-induced adrenocortical neoplasia in the mouse and ferret.Molecular and cellular endocrinology · 2015Article
- Adrenocortical zonation, renewal, and remodeling.Frontiers in endocrinology · 2015Review
- Laser capture microdissection-reduced representation bisulfite sequencing (LCM-RRBS) maps changes in DNA methylation associated with gonadectomy-induced adrenocortical neoplasia in the mouse.Nucleic acids research · 2013Article
- Transgenic GATA-4 expression induces adrenocortical tumorigenesis in C57Bl/6 mice.Journal of cell science · 2013Article
- Reproductive capability is associated with lifespan and cause of death in companion dogs.PloS one · 2013Article
- GATA4 is a critical regulator of gonadectomy-induced adrenocortical tumorigenesis in mice.Endocrinology · 2012Article
- Adrenocortical stem and progenitor cells: implications for adrenocortical carcinoma.Molecular and cellular endocrinology · 2012Review
- Animal models of adrenocortical tumorigenesis.Molecular and cellular endocrinology · 2012Article
- Animal models for aberrations of gonadotropin action.Reviews in endocrine & metabolic disorders · 2011Review
- Concomitant mutations in the P450 oxidoreductase and androgen receptor genes presenting with 46,XY disordered sex development and androgenization at adrenarche.The Journal of clinical endocrinology and metabolism · 2010Article
- Loci controlling lymphocyte production of interferon c after alloantigen stimulation in vitro and their co-localization with genes controlling lymphocyte infiltration of tumors and tumor susceptibility.Cancer immunology, immunotherapy : CII · 2010Article
- Review paper: origin and molecular pathology of adrenocortical neoplasms.Veterinary pathology · 2009Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Postgonadectomy adrenocortical tumorigenesis is a strain-specific phenomenon in inbred mice, assumed to be caused by elevated LH secretion and subsequent ectopic LH receptor (LHR) overexpression in adrenal gland. However, the molecular mechanisms of this cascade of events remain unknown. In this study, we took advantage of the mouse strain dependency of the phenotype to unravel its genetic basis. Our results present the first genome-wide screening related to this pathology in two independent F2 and backcross populations generated between the neoplastic DBA/2J and the nonsusceptible C57BL/6J strains. Surprisingly, the postgonadectomy elevation of serum LH was followed by similar up-regulation of adrenal LHR expression in both parental strains and their crosses, irrespective of their tumor status, indicating that it is not the immediate cause of the tumorigenesis. Linkage analysis revealed one major significant locus for the tumorigenesis on chromosome 8, modulated by epistasis with another quantitative trait locus on chromosome 18. Weight gain, a secondary phenotype after gonadectomy, showed a significant but separate quantitative trait locus on chromosome 7. Altogether, postgonadectomy adrenocortical tumorigenesis in DBA/2J mice is a dominant trait that is not a direct consequence of adrenal LHR expression but is driven by a complex genetic architecture. Analysis of candidate genes in the tumorigenesis linkage region showed that Sfrp1 (secreted frizzled-related protein 1), a tumor suppressor gene, is differentially expressed in the neoplastic areas. These findings may have relevance to the human pathogenesis of macronodular adrenal hyperplasia and adrenocortical tumors in postmenopausal women and why some of them develop obesity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.