ArticleThe Journal of physiology2008
Does elimination of afferent input modify the changes in rat motoneurone properties that occur following chronic spinal cord transection?
Article in The Journal of physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Meta-analysis of biological variables' impact on spinal motoneuron electrophysiology data.Journal of neurophysiology · 2020Pooled it
- KCC2 enhancers normalize reflex responses and improve locomotor function after chronic spinal cord injury.The Journal of physiology · 2025Article
- Low oral dose of 4-methylumbelliferone reduces glial scar but is insufficient to induce functional recovery after spinal cord injury.Scientific reports · 2023Article
- The electrophysiological properties of hindlimb motoneurons do not differ between male and female rats.The European journal of neuroscience · 2022Article
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- Retracing your footsteps: developmental insights to spinal network plasticity following injury.Journal of neurophysiology · 2018Review
- Improvements in bladder, bowel and sexual outcomes following task-specific locomotor training in human spinal cord injury.PloS one · 2018Article
- Spinal Hyper-Excitability and Altered Muscle Structure Contribute to Muscle Hypertonia in Newborns After Antenatal Hypoxia-Ischemia in a Rabbit Cerebral Palsy Model.Frontiers in neurology · 2018Article
- α-Motoneurons maintain biophysical heterogeneity in obesity and diabetes in Zucker rats.Journal of neurophysiology · 2017Article
- Rehabilitation Strategies after Spinal Cord Injury: Inquiry into the Mechanisms of Success and Failure.Journal of neurotrauma · 2017Review
- Characterization of Involuntary Contractions after Spinal Cord Injury Reveals Associations between Physiological and Self-Reported Measures of Spasticity.Frontiers in integrative neuroscience · 2017Article
- Effects of exercise training on urinary tract function after spinal cord injury.American journal of physiology. Renal physiology · 2016Article
- Decrease of mRNA Editing after Spinal Cord Injury is Caused by Down-regulation of ADAR2 that is Triggered by Inflammatory Response.Scientific reports · 2015Article
- Extensor motoneurone properties are altered immediately before and during fictive locomotion in the adult decerebrate rat.The Journal of physiology · 2015Article
- Locomotor training modifies soleus monosynaptic motoneuron responses in human spinal cord injury.Experimental brain research · 2015Article
- Motor unit firing rates during spasms in thenar muscles of spinal cord injured subjects.Frontiers in human neuroscience · 2014Article
- Article
- HCN4 subunit expression in fast-spiking interneurons of the rat spinal cord and hippocampus.Neuroscience · 2013Article
- Differential effects of brain-derived neurotrophic factor and neurotrophin-3 on hindlimb function in paraplegic rats.The European journal of neuroscience · 2012Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
The purpose of this study was to determine the effects of 6-8 weeks of chronic spinal cord isolation (SI, removal of descending, ascending and afferent inputs), compared with the same duration of spinal cord transection (ST, removal of descending input only) on hindlimb motoneurone biophysical properties. Adult female Sprague-Dawley rats were placed into three groups: (1) control (no removal of inputs), (2) ST and (3) SI. The electrophysiological properties from sciatic nerve motoneurones were recorded from deeply anaesthetized rats. Motoneurones in SI rats had significantly (P < 0.01) lower rheobase currents and higher spike afterhyperpolarization amplitudes and input resistances compared with motoneurones in control rats. A higher percentage (chi2, P = 0.01) of motoneurones in SI than control rats demonstrated frequency-current (f-I) relationships consistent with activation of persistent inward currents. Motoneurone steady state f-I slopes determined by increasing steps of 500 ms current pulses were significantly lower (P < 0.02) in SI than control rats. Motoneurone spike frequency adaptation measured using 30 s square-wave current injections (1.5-3.0 nA above the estimated rhythmic firing threshold), was similar for control and SI motoneurones. Changes in motoneurone properties following SI did not differ from ST. These findings indicate that the removal of afferent and ascending inputs along with descending inputs has little additional affect on motoneurone properties than removal of descending inputs alone. This study is the first to demonstrate that intact ascending and afferent input does not modify the effects of spinal transection on basic and rhythmic firing properties of rat hindlimb motoneurones.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.