ArticleNeuroscience2007
Pancreatic innervation in mouse development and beta-cell regeneration.
Article in Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 47 citations in OpenAlex.
- The bile acid-sensive ion channel (BASIC) is expressed in pancreatic α-cells and involved in glucagon secretion.Pflugers Archiv : European journal of physiology · 2026Review
- The nerve center of organ engineering.Nature communications · 2025Review
- Review
- Article
- Development of a 3D atlas of the embryonic pancreas for topological and quantitative analysis of heterologous cell interactions.Development (Cambridge, England) · 2022Article
- Roles of the nervous system in pancreatic cancer.Annals of gastroenterological surgery · 2021Review
- Pancreatic β-cell heterogeneity in health and diabetes: classes, sources, and subtypes.American journal of physiology. Endocrinology and metabolism · 2021Review
- Transcriptomic and Quantitative Proteomic Profiling Reveals Signaling Pathways Critical for Pancreatic Islet Maturation.Endocrinology · 2020Article
- Nerves in cancer.Nature reviews. Cancer · 2020Review
- TRPV1 neurons regulate β-cell function in a sex-dependent manner.Molecular metabolism · 2018Article
- Robo signalling controls pancreatic progenitor identity by regulating Tead transcription factors.Nature communications · 2018Article
- Impact of islet architecture on β-cell heterogeneity, plasticity and function.Nature reviews. Endocrinology · 2016Review
- Article
- Expression and functional studies of the GDNF family receptor alpha 3 in the pancreas.Journal of molecular endocrinology · 2016Article
- Characterization of pancreatic NMDA receptors as possible drug targets for diabetes treatment.Nature medicine · 2015Article
- The neural milieu of the developing choroid plexus: neural stem cells, neurons and innervation.Frontiers in neuroscience · 2015Article
- Vascular endothelial growth factor coordinates islet innervation via vascular scaffolding.Development (Cambridge, England) · 2014Article
- Ontogeny of neuro-insular complexes and islets innervation in the human pancreas.Frontiers in endocrinology · 2014Article
- Review
- Sympathetic innervation during development is necessary for pancreatic islet architecture and functional maturation.Cell reports · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Pancreatic innervation is being viewed with increasing interest with respect to pancreatic disease. At the same time, relatively little is currently known about innervation dynamics during development and disease. The present study employs confocal microscopy to analyze the growth and development of sympathetic and sensory neurons and astroglia during pancreatic organogenesis and maturation. Our research reveals that islet innervation is closely linked to the process of islet maturation-neural cell bodies undergo intrapancreatic migration/shuffling in tandem with endocrine cells, and close neuro-endocrine contacts are established quite early in pancreatic development. In addition, we have assayed the effects of large-scale beta-cell loss and repopulation on the maintenance of islet innervation with respect to particular neuron types. We demonstrate that depletion of the beta-cell population in the rat insulin promoter (RIP)-cmyc(ER) mouse line has cell-type-specific effects on postganglionic sympathetic neurons and pancreatic astroglia. This study contributes to a greater understanding of how cooperating physiological systems develop together and coordinate their functions, and also helps to elucidate how permutation of one organ system through stress or disease can specifically affect parallel systems in an organism.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.