ArticleInternational journal for parasitology2008
Exoerythrocytic development of Plasmodium gallinaceum in the White Leghorn chicken.
Article in International journal for parasitology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 36 citations in OpenAlex.
- The efficacy of artesunate, chloroquine, doxycycline, primaquine and a combination of artesunate and primaquine against avian malaria in broilers.The Journal of veterinary medical science · 2014Trial
- Chickens treated with a nitric oxide inhibitor became more resistant to Plasmodium gallinaceum infection due to reduced anemia, thrombocytopenia and inflammation.Veterinary research · 2013Trial
- Unraveling the host range ofParasitology · 2025Article
- Avian haemosporidian parasites affecting non-descript village chickens in Africa.Tropical animal health and production · 2025Review
- Overview ofComparative medicine · 2024Review
- Limited Plasmodium sporozoite gliding motility in the absence of TRAP family adhesins.Malaria journal · 2021Article
- Aedes aegypti SGS1 is critical for Plasmodium gallinaceum infection of both the mosquito midgut and salivary glands.Malaria journal · 2021Article
- Exo-erythrocytic development of avian malaria and related haemosporidian parasites.Malaria journal · 2017Review
- Progress in imaging methods: insights gained into Plasmodium biology.Nature reviews. Microbiology · 2017Review
- The Strategy to Survive Primary Malaria Infection: An Experimental Study on Behavioural Changes in Parasitized Birds.PloS one · 2016Article
- Imaging Plasmodium immunobiology in the liver, brain, and lung.Parasitology international · 2014Review
- Looking under the skin: the first steps in malarial infection and immunity.Nature reviews. Microbiology · 2013Review
- Identification and expression of maebl, an erythrocyte-binding gene, in Plasmodium gallinaceum.Parasitology research · 2013Article
- Plasmodium yoelii sporozoites modulate cytokine profile and induce apoptosis in murine Kupffer cells.International journal for parasitology · 2008Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Plasmodium gallinaceum typically causes sub-clinical disease with low mortality in its primary host, the Indian jungle fowl Gallus sonnerati. Domestic chickens of European origin, however, are highly susceptible to this avian malaria parasite. Here we describe the development of P. gallinaceum in young White Leghorn chicks with emphasis on the primary exoerythrocytic phase of the infection. Using various regimens for infection, we found that P. gallinaceum induced a transient primary exoerythrocytic infection followed by a fulminant lethal erythrocytic phase. Prerequisite for the appearance of secondary exoerythrocytic stages was the development of a certain level of parasitaemia. Once established, secondary exoerythrocytic stages could be propagated from bird to bird for several generations without causing fatalities. Infected brains contained large secondary exoerythrocytic stages in capillary endothelia, while in the liver primary and secondary erythrocytic stages developed primarily in Kupffer cells and remained smaller. At later stages, livers exhibited focal hepatocyte necrosis, Kupffer cell hyperplasia, stellate cell proliferation, inflammatory cell infiltration and granuloma formation. Because P. gallinaceum selectively infected Kupffer cells in the liver and caused a histopathology strikingly similar to mammalian species, this avian Plasmodium species represents an evolutionarily closely related model for studies on the hepatic phase of mammalian malaria.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.