ArticleCell host & microbe2007
Antibodies to West Nile virus: a double-edged sword.
Article in Cell host & microbe, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- Antiviral neutralizing antibodies: from in vitro to in vivo activity.Nature reviews. Immunology · 2023Review
- Engineering Materials and Devices for the Prevention, Diagnosis, and Treatment of COVID-19 and Infectious Diseases.Nanomaterials (Basel, Switzerland) · 2023Review
- Fruitful Neutralizing Antibody Pipeline Brings Hope To Defeat SARS-Cov-2.Trends in pharmacological sciences · 2020Review
- A game of numbers: the stoichiometry of antibody-mediated neutralization of flavivirus infection.Progress in molecular biology and translational science · 2015Review
- Review
- Unusual features of vaccinia virus extracellular virion form neutralization resistance revealed in human antibody responses to the smallpox vaccine.Journal of virology · 2013Article
- Review
- Heavily isotype-dependent protective activities of human antibodies against vaccinia virus extracellular virion antigen B5.Journal of virology · 2009Article
- Vaccinia virus extracellular enveloped virion neutralization in vitro and protection in vivo depend on complement.Journal of virology · 2009Article
- The structural immunology of antibody protection against West Nile virus.Immunological reviews · 2008Review
- Article
- The growth and potential of human antiviral monoclonal antibody therapeutics.Nature biotechnology · 2007Review
- Monoclonal antibodies for prophylactic and therapeutic use against viral infections.Pediatria polskaReview
- Neutralization of Virus Infectivity by Antibodies: Old Problems in New Perspectives.Advances in biologyArticle
Corrections and comments
- Comment on
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antibodies, although critical for host defense against West Nile virus (WNV), can both neutralize and enhance viral infection. In this issue of Cell Host & Microbe, Pierson et al. dissect these opposing effects and demonstrate that, when 120 epitopes are available per WNV virion, approximately 25 are occupied by antibody at 50% neutralization. At lower occupancies, enhancement of infection dominates; at higher ones, neutralization ensues. These results are important for WNV vaccine design and for potential therapeutic use of antibodies to WNV.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.