ArticleIntensive care medicine2008
Cardiac morphological and functional changes during early septic shock: a transesophageal echocardiographic study.
Article in Intensive care medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02770183 (Rate of Left Ventricular Systolic Function's Recuperation After Cardiac Surgery With Extracorporeal Circulation.), which is not on this map. Cited by 35 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Rate of Left Ventricular Systolic Function's Recuperation After Cardiac Surgery With Extracorporeal Circulation.
Who cites it
35 citing papers in PubMed, 3 syntheses or guidelines pooled it, 105 citations in OpenAlex.
- Diastolic dysfunction and mortality in septic patients: a systematic review and meta-analysis.Intensive care medicine · 2015Pooled it
- Is early ventricular dysfunction or dilatation associated with lower mortality rate in adult severe sepsis and septic shock? A meta-analysis.Critical care (London, England) · 2013Pooled it
- Echocardiography practice, training and accreditation in the intensive care: document for the World Interactive Network Focused on Critical Ultrasound (WINFOCUS).Cardiovascular ultrasound · 2008Guideline
- A pilot study on safety and clinical utility of a single-use 72-hour indwelling transesophageal echocardiography probe.Intensive care medicine · 2013Trial
- The Emerging Role and Clinical Utility of Transnasal Transesophageal Echocardiography.Echocardiography (Mount Kisco, N.Y.) · 2026Review
- Incidence and Prognostic Impact of Myocardial Dysfunction in Septic Shock: An Observational Cohort Study.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2026Article
- Septic Cardiomyopathy: Difficult Definition, Challenging Diagnosis, Unclear Treatment.Journal of clinical medicine · 2025Review
- Left ventricular diastolic dysfunction is prevalent but not associated with mortality in patients with septic shock.Intensive care medicine · 2025Observational
- Venoarterial extracorporeal membrane oxygenation for septic cardiomyopathy caused by Pasteurella multocida infection: a case report.Journal of anesthesia · 2022Article
- Clinical impact of visually assessed right ventricular dysfunction in patients with septic shock.Scientific reports · 2021Article
- Sepsis-induced cardiomyopathy is associated with higher mortality rates in patients with sepsis.Acute and critical care · 2021Article
- Afterload-related cardiac performance identifies cardiac impairment and associates with outcome in patients with septic shock: a retrospective cohort study.Journal of intensive care · 2021Article
- Ultrasonography in the Critical Care Unit.Current cardiology reports · 2020Review
- Continuous cardiac output assessment or serial echocardiography during septic shock resuscitation?Annals of translational medicine · 2020Review
- Predictors and outcomes of sepsis-induced cardiomyopathy in critically ill patients.Acute and critical care · 2020Article
- A simplified definition of diastolic function in sepsis, compared against standard definitions.Journal of intensive care · 2019Article
- Echocardiographic parameters of patients in the intensive care unit undergoing continuous renal replacement therapy.PloS one · 2019Article
- Article
- Associations among left ventricular systolic function, tachycardia, and cardiac preload in septic patients.Annals of intensive care · 2017Article
- Left ventricular systolic dysfunction during septic shock: the role of loading conditions.Intensive care medicine · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe objective was to prospectively evaluate cardiac morphological and functional changes using transesophageal echocardiography (TEE) during early septic shock.
designProspective, observational study.
settingMedical-surgical intensive care unit of a teaching hospital. PATIENTS AND
participantsVentilated patients with septic shock, sinus rhythm and no cardiac disease underwent TEE within 12h of admission (Day0), after stabilization of hemodynamics by fluid loading (median volume: 4.9l [lower and upper quartiles: 3.7-9.6l]) and vasopressor therapy, and after vasopressors were stopped (Dayn). MEASUREMENTS AND
resultsThirty-five patients were studied (median age: 60 years [range 44-68]; SAPS II: 53 [46-62]; SOFA score: 9 [8-11]) and 9 of them (26%) died while on vasopressors. None of the patients exhibited TEE findings of cardiac preload dependence. Between Day0 and Dayn (7 days [range 6-9]), mean left ventricular (LV) ejection fraction (EF) increased (47 +/- 20 vs. 57 +/- 14%: p < 0.05), whereas mean LV end-diastolic volume decreased (97 +/- 25 vs. 75 +/- 20ml: p < 0.0001). Out of 16 patients (46%) with LV systolic dysfunction on Day0, 12 had normal LVEF on Dayn and 4 patients fully recovered by Day28. Only 4 women had LV dilatation (range, LV end-diastolic volume: 110-148ml) on Day0, but none on Dayn. Doppler tissue imaging identified an LV diastolic dysfunction in 7 patients (20%) on Day0 (3 with normal LVEF), which resolved on Dayn.
conclusionsThis study confirms that LV systolic and diastolic dysfunctions are frequent, but LV dilatation is uncommon in fluid-loaded septic patients on vasopressors. All abnormalities regressed in survivors, regardless of their severity. DESCRIPTORS: Shock: clinical studies (38), Cardiovascular monitoring (34).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.