ArticleProceedings of the National Academy of Sciences of the United States of America2007
Separate functions for nuclear and cytoplasmic cryptochrome 1 during photomorphogenesis of Arabidopsis seedlings.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed, 126 citations in OpenAlex.
- Cryptochrome-mediated signaling in root development.The New phytologist · 2026Review
- A CRY1 Interactor eIF3G1 Negatively Regulates Root Growth Under Blue Light inPlants (Basel, Switzerland) · 2026Article
- Integrated multi-omics analysis reveals the regulatory mechanism of cryptochrome 1- mediated anthocyanin biosynthesis in Populus trichocarpa.BMC plant biology · 2026Article
- Strawberry cryptochrome FvCRY1 and FvCRY2 transcriptionally regulate anthocyanin biosynthesis and sugar metabolism.Molecular horticulture · 2025Article
- Transcriptomic insights into gibberellin-3-mediated regulation of bud dormancy and metabolic transition in pitaya (Hylocereus polyrhizus).Plant cell reports · 2025Article
- Cryptochrome 1 in the dark affects phytochrome A in etiolated Arabidopsis seedlings shifting the balance between its native types, phyA' and phyA″.Protoplasma · 2025Article
- Genome-wide characterization of ZmCRY genes: unveiling stress response mechanisms and the role of ZmCRYPHR2 in salinity tolerance.BMC plant biology · 2025Article
- Phytochrome E Plays a Role in the Suppression of Germination in Far-Red Light in Tomato.Plant direct · 2025Article
- Red and blue photo-selective nets optimize leaf photostructure and photosynthetic efficiency to enhance antioxidant capacity, yield, and quality in adzuki bean.Frontiers in plant science · 2025Article
- Light signaling in plants-a selective history.Plant physiology · 2024Review
- Diurnal Rhythms in the Red Seaweed Gracilariopsis chorda are Characterized by Unique Regulatory Networks of Carbon Metabolism.Molecular biology and evolution · 2024Article
- Genome-wide identification and transcriptome profiling expression analysis of the U-box E3 ubiquitin ligase gene family related to abiotic stress in maize (Zea mays L.).BMC genomics · 2024Article
- Genome-wide identification and expression analysis of the cryptochromes reveal theFrontiers in plant science · 2024Article
- Effect of the Enhanced Production of ChlorophyllInternational journal of molecular sciences · 2023Article
- Transcriptome analysis and phenotyping of walnut seedling roots under nitrogen stresses.Scientific reports · 2022Article
- Functions of COP1/SPA E3 Ubiquitin Ligase Mediated by MpCRY in the LiverwortInternational journal of molecular sciences · 2021Article
- Perception of solar UV radiation by plants: photoreceptors and mechanisms.Plant physiology · 2021Article
- Cryptochromes and the Circadian Clock: The Story of a Very Complex Relationship in a Spinning World.Genes · 2021Review
- Light-Induced Dynamic Change of Phytochrome B and Cryptochrome 1 Stabilizes SINATs inFrontiers in plant science · 2021Article
- Photoexcited Cryptochrome2 Interacts Directly with TOE1 and TOE2 in Flowering Regulation.Plant physiology · 2020Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cryptochrome blue-light receptors mediate many aspects of plant photomorphogenesis, such as suppression of hypocotyl elongation and promotion of cotyledon expansion and root growth. The cryptochrome 1 (cry1) protein of Arabidopsis is present in the nucleus and cytoplasm of cells, but how the functions of one pool differ from the other is not known. Nuclear localization and nuclear export signals were genetically engineered into GFP-tagged cry1 molecules to manipulate cry1 subcellular localization in a cry1-null mutant background. The effectiveness of the engineering was confirmed by confocal microscopy. The ability of nuclear or cytoplasmic cry1 to rescue a variety of cry1 phenotypes was determined. Hypocotyl growth suppression by blue light was assessed by standard end-point analyses and over time with high resolution by a custom computer-vision technique. Both assays indicated that nuclear, rather than cytoplasmic, cry1 was the effective molecule in these growth inhibitions, as was the case for the mechanistically linked membrane depolarization, which occurs within several seconds of cry1 activation. Petiole elongation also was inhibited by nuclear, but not cytoplasmic, cry1. Conversely, primary root growth and cotyledon expansion in blue light were promoted by cytoplasmic cry1 and inhibited by nuclear cry1. Anthocyanin production in response to blue light was strongly stimulated by nuclear cry1 and, to a lesser extent, by cytoplasmic cry1. An important step toward elucidation of cry1 signaling pathways is the recognition that different subcellular pools of the photoreceptor have different functions.
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