ArticleProceedings of the National Academy of Sciences of the United States of America2007
Simpler mode of inheritance of transcriptional variation in male Drosophila melanogaster.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 52 citations in OpenAlex.
- Organization and evolution of sex-biased gene expression inbioRxiv : the preprint server for biology · 2026Article
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- Nonlinear expression patterns and multiple shifts in gene network interactions underlie robust phenotypic change in Drosophila melanogaster selected for night sleep duration.PLoS computational biology · 2023Article
- Identification of Genes Contributing to a Long Circadian Period inJournal of biological rhythms · 2021Article
- Uncovering hidden genetic variation in photosynthesis of field-grown maize under ozone pollution.Global change biology · 2019Article
- Genome-Wide Association Study of Circadian Behavior in Drosophila melanogaster.Behavior genetics · 2019Article
- The Evolution of Gene Expression in cis and trans.Trends in genetics : TIG · 2018Review
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- Microenvironmental Gene Expression Plasticity Among Individual Drosophila melanogaster.G3 (Bethesda, Md.) · 2016Article
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- The Wright stuff: reimagining path analysis reveals novel components of the sex determination hierarchy in Drosophila melanogaster.BMC systems biology · 2015Article
- Gene Expression Evolves under a House-of-Cards Model of Stabilizing Selection.Molecular biology and evolution · 2015Article
- The evolution and adaptive potential of transcriptional variation in sticklebacks--signatures of selection and widespread heritability.Molecular biology and evolution · 2015Article
- Sex-biased gene expression and sexual conflict throughout development.Cold Spring Harbor perspectives in biology · 2014Review
- The ontogeny and evolution of sex-biased gene expression in Drosophila melanogaster.Molecular biology and evolution · 2014Article
- What the X has to do with it: differences in regulatory variability between the sexes in Drosophila simulans.Genome biology and evolution · 2014Article
- Genome-wide gene expression effects of sex chromosome imprinting in Drosophila.G3 (Bethesda, Md.) · 2014Article
- Article
- Implications of sex-specific selection for the genetic basis of disease.Evolutionary applications · 2013Article
- Congruence of additive and non-additive effects on gene expression estimated from pedigree and SNP data.PLoS genetics · 2013Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
Sexual selection drives faster evolution in males. The X chromosome is potentially an important target for sexual selection, because hemizygosity in males permits accumulation of alleles, causing tradeoffs in fitness between sexes. Hemizygosity of the X could cause fundamentally different modes of inheritance between the sexes, with more additive variation in males and more nonadditive variation in females. Indeed, we find that genetic variation for the transcriptome is primarily additive in males but nonadditive in females. As expected, these differences are more pronounced on the X chromosome than the autosomes, but autosomal loci are also affected, possibly because of X-linked transcription factors. These differences may be of evolutionary significance because additive variation responds quickly to selection, whereas nonadditive genetic variation does not. Thus, hemizygosity of the X may underlie much of the faster male evolution of the transcriptome and potentially other phenotypes. Consistent with this prediction, genes that are additive in males and nonadditive in females are overrepresented among genes responding to selection for increased mating speed.
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