ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Long-term plasticity of the spinal locomotor circuitry mediated by endocannabinoid and nitric oxide signaling.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 58 citations in OpenAlex.
- What Else Can Be Done by the Spinal Cord? A Review on the Effectiveness of Transpinal Direct Current Stimulation (tsDCS) in Stroke Recovery.International journal of molecular sciences · 2023Review
- In Vivo Evaluation ofPharmaceuticals (Basel, Switzerland) · 2021Article
- Developmentally Regulated Modulation of Lumbar Motoneurons by Metabotropic Glutamate Receptors: A Cellular and Behavioral Analysis in Newborn Mice.Frontiers in cellular neuroscience · 2021Article
- CB1 cannabinoid receptor-mediated plasticity of GABAergic synapses in the mouse insular cortex.Scientific reports · 2020Article
- Lights on Endocannabinoid-Mediated Synaptic Potentiation.Frontiers in molecular neuroscience · 2020Review
- Principles Governing Locomotion in Vertebrates: Lessons From Zebrafish.Frontiers in neural circuits · 2018Review
- A behaviorally related developmental switch in nitrergic modulation of locomotor rhythmogenesis in larval Xenopus tadpoles.Journal of neurophysiology · 2016Article
- Physical activity and the endocannabinoid system: an overview.Cellular and molecular life sciences : CMLS · 2014Review
- Nitric oxide-mediated modulation of the murine locomotor network.Journal of neurophysiology · 2014Article
- The evolution and comparative neurobiology of endocannabinoid signalling.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2012Review
- Tonic and transient endocannabinoid regulation of AMPAergic miniature postsynaptic currents and homeostatic plasticity in embryonic motor networks.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Modulation of circuit feedback specifies motor circuit output.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Gating the polarity of endocannabinoid-mediated synaptic plasticity by nitric oxide in the spinal locomotor network.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Neuromodulation and flexibility in Central Pattern Generator networks.Current opinion in neurobiology · 2011Review
- Endocannabinoids gate state-dependent plasticity of synaptic inhibition in feeding circuits.Neuron · 2011Article
- Initiation of locomotion in adult zebrafish.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Activation of group I metabotropic glutamate receptors modulates locomotor-related motoneuron output in mice.Journal of neurophysiology · 2011Article
- General principles of rhythmogenesis in central pattern generator networks.Progress in brain research · 2010Article
- Measured motion: searching for simplicity in spinal locomotor networks.Current opinion in neurobiology · 2009Review
- The nitric oxide/cGMP pathway tunes the thermosensitivity of swimming motor patterns in Xenopus laevis tadpoles.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Retrograde signaling by endocannabinoids is known to induce short- and long-term synaptic plasticity, but the significance of this modulation for the activity of neural networks underlying motor behavior is largely unclear. Here, we used the isolated lamprey spinal cord to show that endocannabinoids released by activation of metabotropic glutamate receptor 1 (mGluR1) induce long-term synaptic plasticity during an ongoing locomotor rhythm and how this is translated onto the integrated activity of the spinal circuitry. A brief activation of mGluR1 induces a long-term increase in the locomotor frequency that is mediated by a concomitant long-term depression of midcycle reciprocal inhibition and long-term potentiation of ipsilateral synaptic excitation arising from locomotor circuit interneurons. Blockade of cannabinoid receptors with AM251 prevented the mGluR1-mediated long-term plasticity of both inhibitory and excitatory synaptic transmission, as well as that of the locomotor activity. Similarly, inhibition of nitric oxide signaling blocked the mGluR1-mediated long-term plasticity. These results show that the locomotor circuitry is endowed with a "memory" capacity mediated by a long-term shift in the balance between synaptic inhibition and excitation. This is triggered by activation of mGluR1 and requires subsequent endocannabinoid and nitric oxide signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.