ArticleBiostatistics (Oxford, England)2008
Genetic model selection in two-phase analysis for case-control association studies.
Article in Biostatistics (Oxford, England), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Combined effects of maternal periconceptional environmental exposures and infant cardiac transcription factor polymorphisms on congenital heart disease risk.Annals of medicine · 2026Article
- Effect of THBS1 and P21 Gene Polymorphisms and Their Interaction On Risk of Pre-eclampsia.Reproductive sciences (Thousand Oaks, Calif.) · 2025Article
- Association of polymorphisms of FOLR1 gene and FOLR2 gene and maternal folic acid supplementation with risk of ventricular septal defect: a case-control study.European journal of clinical nutrition · 2022Article
- Association of MTHFD1 gene polymorphisms and maternal smoking with risk of congenital heart disease: a hospital-based case-control study.BMC pregnancy and childbirth · 2022Article
- Association of methylenetetrahydrofolate reductase gene polymorphisms and maternal folic acid use with the risk of congenital heart disease.Frontiers in pediatrics · 2022Article
- Quantitative Trait Loci Identification by Estimating the Genetic Model based on the Extremal Samples.Current genomics · 2021Review
- Article
- Two GWAS-identified variants are associated with lumbar spinal stenosis and Gasdermin-C expression in Chinese population.Scientific reports · 2020Article
- Two-phase SSU and SKAT in genetic association studies.Journal of genetics · 2020Article
- Power and Sample Size Calculations for Genetic Association Studies in the Presence of Genetic Model Misspecification.Human heredity · 2019Article
- Genetic model misspecification in genetic association studies.BMC research notes · 2017Article
- Fitting Proportional Odds Model to Case-Control data with Incorporating Hardy-Weinberg Equilibrium.Scientific reports · 2015Article
- Robust Association Tests for the Replication of Genome-Wide Association Studies.BioMed research international · 2015Article
- A new association test based on disease allele selection for case-control genome-wide association studies.BMC genomics · 2014Article
- A new system identification approach to identify genetic variants in sequencing studies for a binary phenotype.Human heredity · 2014Article
- Incorporating parental information into family-based association tests.Biostatistics (Oxford, England) · 2013Article
- Case-Control Genome-wide Joint Association Study Using Semiparametric Empirical Model and Approximate Bayes Factor.Journal of statistical computation and simulation · 2013Article
- Article
- Design and analysis of multiple diseases genome-wide association studies without controls.Gene · 2012Article
- Bayes factor based on the trend test incorporating Hardy-Weinberg disequilibrium: more power to detect genetic association.Annals of human genetics · 2012Article
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2 authors.
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Abstract
The Cochran-Armitage trend test (CATT) is well suited for testing association between a marker and a disease in case-control studies. When the underlying genetic model for the disease is known, the CATT optimal for the genetic model is used. For complex diseases, however, the genetic models of the true disease loci are unknown. In this situation, robust tests are preferable. We propose a two-phase analysis with model selection for the case-control design. In the first phase, we use the difference of Hardy-Weinberg disequilibrium coefficients between the cases and the controls for model selection. Then, an optimal CATT corresponding to the selected model is used for testing association. The correlation of the statistics used for selection and the test for association is derived to adjust the two-phase analysis with control of the Type-I error rate. The simulation studies show that this new approach has greater efficiency robustness than the existing methods.
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