ArticleJournal of molecular and cellular cardiology2008
Cardiac sulfonylurea receptor short form-based channels confer a glibenclamide-insensitive KATP activity.
Article in Journal of molecular and cellular cardiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 42 citations in OpenAlex.
- Expression of SUR1 isoforms in the brain and heart after ischemia/reperfusion.Frontiers in molecular neuroscience · 2025Article
- The short form of the SUR1 and its functional implications in the damaged brain.Neural regeneration research · 2022Review
- Complex consequences of Cantu syndrome SUR2 variant R1154Q in genetically modified mice.JCI insight · 2021Article
- Deletion of Sulfonylurea Receptor 2 in the Adult Myocardium Enhances Cardiac Glucose Uptake and Is Cardioprotective.JACC. Basic to translational science · 2019Article
- Article
- Blocking ATP-sensitive potassium channel alleviates morphine tolerance by inhibiting HSP70-TLR4-NLRP3-mediated neuroinflammation.Journal of neuroinflammation · 2017Article
- KATP channels in high glucose-induced rat mesangial cell proliferation and release of MMP-2 and fibronectin.Experimental and therapeutic medicine · 2017Article
- The Slo(w) path to identifying the mitochondrial channels responsible for ischemic protection.The Biochemical journal · 2017Review
- Abcc9 is required for the transition to oxidative metabolism in the newborn heart.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Article
- Natriuretic peptides modulate ATP-sensitive K(+) channels in rat ventricular cardiomyocytes.Basic research in cardiology · 2014Article
- Disrupting KATP channels diminishes the estrogen-mediated protection in female mutant mice during ischemia-reperfusion.Clinical proteomics · 2014Article
- The interaction of caveolin 3 protein with the potassium inward rectifier channel Kir2.1: physiology and pathology related to long qt syndrome 9 (LQT9).The Journal of biological chemistry · 2013Article
- Kir6.2 is not the mitochondrial KATP channel but is required for cardioprotection by ischemic preconditioning.American journal of physiology. Heart and circulatory physiology · 2013Article
- KATP channels and cardiovascular disease: suddenly a syndrome.Circulation research · 2013Review
- Measuring and evaluating the role of ATP-sensitive K+ channels in cardiac muscle.Journal of molecular and cellular cardiology · 2012Review
- Article
- Vasodilation induced by oxygen/glucose deprivation is attenuated in cerebral arteries of SUR2 null mice.American journal of physiology. Heart and circulatory physiology · 2011Article
- Hydrogen sulfide dilates cerebral arterioles by activating smooth muscle cell plasma membrane KATP channels.American journal of physiology. Heart and circulatory physiology · 2011Article
- Vascular ATP-sensitive potassium channels are over-expressed and partially regulated by nitric oxide in experimental septic shock.Intensive care medicine · 2011Article
- The mitochondrial bioenergetic phenotype for protection from cardiac ischemia in SUR2 mutant mice.American journal of physiology. Heart and circulatory physiology · 2010Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The cardiac sarcolemmal ATP-sensitive potassium channel (K(ATP)) consists of a Kir6.2 pore and an SUR2 regulatory subunit, which is an ATP-binding cassette (ABC) transporter. K(ATP) channels have been proposed to play protective roles during ischemic preconditioning. An SUR2 mutant mouse was previously generated by disrupting the first nucleotide-binding domain (NBD1), where a glibenclamide action site was located. In the mutant ventricular myocytes, a non-conventional glibenclamide-insensitive (10 microM), ATP-sensitive current (I(KATPn)) was detected in 33% of single-channel recordings with an average amplitude of 12.3+/-5.4 pA per patch, an IC(50) to ATP inhibition at 10 microM and a mean burst duration at 20.6+/-1.8 ms. Newly designed SUR2 isoform- or variant-specific antibodies identified novel SUR2 short forms in the sizes of 28 and 68 kDa in addition to a 150-kDa long form in the sarcolemmal membrane of wild-type (WT) heart. We hypothesized that channels constituted by these short forms that lack NBD1 confer I(KATPn). The absence of the long form in the mutant corresponded to loss of the conventional glibenclamide-sensitive K(ATP) currents (I(KATP)) in isolated cardiomyocytes and vascular smooth muscle cells but the SUR2 short forms remained intact. Nested exonic RT-PCR in the mutant indicated that the short forms lacked NBD1 but contained NBD2. The SUR2 short forms co-immunoprecipitated with Kir6.1 or Kir6.2 suggesting that the short forms may function as hemi-transporters reported in other eukaryotic ABC transporter subgroups. Our results indicate that different K(ATP) compositions may co-exist in cardiac sarcolemmal membrane.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.