ArticleArthritis research & therapy2007
Association of ITGAV supports a role of angiogenesis in rheumatoid arthritis.
Article in Arthritis research & therapy, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- The ITGAV rs3738919 variant and susceptibility to rheumatoid arthritis in four Caucasian sample sets.Arthritis research & therapy · 2009Pooled it
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- Network analysis of synovial RNA sequencing identifies gene-gene interactions predictive of response in rheumatoid arthritis.Arthritis research & therapy · 2022Article
- Cardiac aging is initiated by matrix metalloproteinase-9-mediated endothelial dysfunction.American journal of physiology. Heart and circulatory physiology · 2014Article
- Angiogenesis and its targeting in rheumatoid arthritis.Vascular pharmacology · 2009Review
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2 authors at 1 institution in 1 country.
Funding
Abstract
Motivated by linkage data and the hypothesis that angiogenesis plays a functional role in rheumatoid arthritis (RA), Jacq and colleagues present a family-based, multi-stage, candidate gene association study in French and European Caucasians in a paper on the association of the ITGAV rs3738919-C variant allele with RA (C-containing genotypes: odds ratio 1.94, confidence interval 1.3 to 2.9, P = 0.002). Support comes from a recent genome-wide study, which on its own would have missed identifying the association. Further research into the associating variant will require detailed haplotype analysis, verification in further studies, and research involving intermediate phenotypes or direct functional experiments. This new RA risk factor supports the role of angiogenesis in the disease.
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Registered trials
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