ArticleMolecular microbiology2007
Differential Flo8p-dependent regulation of FLO1 and FLO11 for cell-cell and cell-substrate adherence of S. cerevisiae S288c.
Article in Molecular microbiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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43 citing papers in PubMed.
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- Voices of Eukaryotic Microbes: Chemical Communication Via Quorum Sensing.Microbial ecology · 2026Review
- Flo5-1 and Nrg1 are involved in reversible pH-dependent flocculation in Komagataella phaffii.Applied microbiology and biotechnology · 2025Article
- Functional analysis of Saccharomyces cerevisiae FLO genes through optogenetic control.FEMS yeast research · 2025Article
- The origins of the Guinness stout yeast.Communications biology · 2024Article
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- Antibiofilm Effect of Curcumin onBiomolecules · 2023Article
- Heterologous Expression ofJournal of fungi (Basel, Switzerland) · 2022Article
- Adhesion as a Focus in Trichoderma-Root Interactions.Journal of fungi (Basel, Switzerland) · 2022Review
- Pathogenic Process-Associated Transcriptome Analysis ofInternational journal of genomics · 2022Article
- Elucidating the regulatory mechanism of Swi1 prion in global transcription and stress responses.Scientific reports · 2020Article
- The Transcription Factor SomA Synchronously Regulates Biofilm Formation and Cell Wall Homeostasis inmBio · 2020Article
- Diverse roles of Tup1p and Cyc8p transcription regulators in the development of distinct types of yeast populations.Current genetics · 2019Review
- Cyc8p and Tup1p transcription regulators antagonistically regulate Flo11p expression and complexity of yeast colony biofilms.PLoS genetics · 2018Article
- Transcriptome profiling of Issatchenkia orientalis under ethanol stress.AMB Express · 2018Article
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- Expansion of a TelomericFrontiers in genetics · 2018Article
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3 authors.
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Abstract
Cell-cell and cell-surface adherence represents initial steps in forming multicellular aggregates or in establishing cell-surface interactions. The commonly used Saccharomyces cerevisiae laboratory strain S288c carries a flo8 mutation, and is only able to express the flocculin-encoding genes FLO1 and FLO11, when FLO8 is restored. We show here that the two flocculin genes exhibit differences in regulation to execute distinct functions under various environmental conditions. In contrast to the laboratory strain Sigma1278b, haploids of the S288c genetic background require FLO1 for cell-cell and cell-substrate adhesion, whereas FLO11 is required for pseudohyphae formation of diploids. In contrast to FLO11, FLO1 repression requires the Sin4p mediator tail component, but is independent of the repressor Sfl1p. FLO1 regulation also differs from FLO11, because it requires neither the KSS1 MAP kinase cascade nor the pathways which lead to the transcription factors Gcn4p or Msn1p. The protein kinase A pathway and the transcription factors Flo8p and Mss11p are the major regulators for FLO1 expression. Therefore, S. cerevisiae is prepared to simultaneously express two genes of its otherwise silenced FLO reservoir resulting in an appropriate cellular surface for different environments.
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