ArticleDevelopmental neurobiology2008
Otoc1: a novel otoconin-90 ortholog required for otolith mineralization in zebrafish.
Article in Developmental neurobiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 46 citations in OpenAlex.
- Evolutionary analysis of genes associated with the sense of balance in semi-aquatic mammals.BMC ecology and evolution · 2025Article
- Knockout ofBiomedicines · 2024Article
- Article
- The Role of Intrinsically Disordered Proteins in Liquid-Liquid Phase Separation during Calcium Carbonate Biomineralization.Biomolecules · 2022Review
- Development and evolution of the vestibular apparatuses of the inner ear.Journal of anatomy · 2021Review
- Turning the Curve Into Straight: Phenogenetics of the Spine Morphology and Coordinate Maintenance in the Zebrafish.Frontiers in cell and developmental biology · 2021Review
- Whole-Genome Sequencing and Genome-Wide Studies of Spiny Head Croaker (Frontiers in genetics · 2021Article
- Benign Paroxysmal Positional Vertigo Risk Factors Unique to Perimenopausal Women.Frontiers in neurology · 2020Review
- Zebrafish otolith biomineralization requires polyketide synthase.Mechanisms of development · 2019Article
- Age-Related Increases in Benign Paroxysmal Positional Vertigo Are Reversed in Women Taking Estrogen Replacement Therapy: A Population-Based Study in Taiwan.Frontiers in aging neuroscience · 2017Article
- Competition between Jagged-Notch and Endothelin1 Signaling Selectively Restricts Cartilage Formation in the Zebrafish Upper Face.PLoS genetics · 2016Article
- Otolith tethering in the zebrafish otic vesicle requires Otogelin and α-Tectorin.Development (Cambridge, England) · 2015Article
- Mechanisms of otoconia and otolith development.Developmental dynamics : an official publication of the American Association of Anatomists · 2015Review
- Alcohol-induced morphological deficits in the development of octavolateral organs of the zebrafish (Danio rerio).Zebrafish · 2013Article
- Bisphenol A induces otolith malformations during vertebrate embryogenesis.BMC developmental biology · 2011Article
- Matrix recruitment and calcium sequestration for spatial specific otoconia development.PloS one · 2011Article
- Expression, functional, and structural analysis of proteins critical for otoconia development.Developmental dynamics : an official publication of the American Association of Anatomists · 2010Article
- Article
- In vitro effects of recombinant otoconin 90 upon calcite crystal growth. Significance of tertiary structure.Hearing research · 2010Article
- Sparc protein is required for normal growth of zebrafish otoliths.Journal of the Association for Research in Otolaryngology : JARO · 2008Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Within the vestibular system of virtually all vertebrate species, gravity and linear acceleration are detected via coupling of calcified masses to the cilia of mechanosensory hair cells. The mammalian ear contains thousands of minute biomineralized particles called otoconia, whereas the inner ear of teleost fish contains three large ear stones called otoliths that serve a similar function. Otoconia and otoliths are composed of calcium carbonate crystals condensed on a core protein lattice. Otoconin-90 (Oc90) is the major matrix protein of mammalian and avian otoconia, while otolith matrix protein (OMP) is the most abundant matrix protein found in the otoliths of teleost fish. We have identified a novel gene, otoc1, which encodes the zebrafish ortholog of Oc90. Expression of otoc1 was detected in the ear between 15 hpf and 72 hpf, and was restricted primarily to the macula and the developing epithelial pillars of the semicircular canals. Expression of otoc1 was also detected in epiphysis, optic stalk, midbrain, diencephalon, flexural organ, and spinal cord. During embryogenesis, expression of otoc1 mRNA preceded the appearance of omp-1 transcripts. Knockdown of otoc1 mRNA translation with antisense morpholinos produced a variety of aberrant otolith phenotypes. Our results suggest that Otoc1 may serve to nucleate calcium carbonate mineralization of aragonitic otoliths.
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