Trial reportMolecular imaging and biology
Phosphocreatine kinetics in the calf muscle of patients with bilateral symptomatic peripheral arterial disease during exhaustive incremental exercise.
Trial report in Molecular imaging and biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Supplemental Oxygen Improves In Vivo Mitochondrial Oxidative Phosphorylation Flux in Sedentary Obese Adults With Type 2 Diabetes.Diabetes · 2018Trial
- Trial
- A Modified Run-Off Resistance Score from Cross-Sectional Imaging Discriminates Chronic Critical Limb Ischemia from Intermittent Claudication in Peripheral Arterial Disease.Diagnostics (Basel, Switzerland) · 2022Article
- Ankle-Brachial Index and Energy Production in People Without Peripheral Artery Disease: The BLSA.Journal of the American Heart Association · 2022Article
- Lower Mitochondrial Energy Production of the Thigh Muscles in Patients With Low-Normal Ankle-Brachial Index.Journal of the American Heart Association · 2017Article
- Blood pressure and calf muscle oxygen extraction during plantar flexion exercise in peripheral artery disease.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Article
- Insulin resistance in type 2 diabetes youth relates to serum free fatty acids and muscle mitochondrial dysfunction.Journal of diabetes and its complications · 2017Article
- Muscle oxygenation during dynamic plantar flexion exercise: combining BOLD MRI with traditional physiological measurements.Physiological reports · 2016Article
- Method for controlled mitochondrial perturbation during phosphorus MRS in children.Medicine and science in sports and exercise · 2014Article
- Oxygenation and flow in the limbs: Novel methods to characterize peripheral artery disease.Current cardiovascular imaging reports · 2013Article
- Exercise training and peripheral arterial disease.Comprehensive Physiology · 2012Review
- Magnetic resonance spectroscopy studies of human metabolism.Diabetes · 2011Article
- Phosphocreatine recovery overshoot after high intensity exercise in human skeletal muscle is associated with extensive muscle acidification and a significant decrease in phosphorylation potential.The journal of physiological sciences : JPS · 2010Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate the relationship between the atherosclerotic lesion load determined on magnetic resonance angiography (MRA) and phosphocreatine (PCr) kinetics during incremental, exhaustive calf exercise in patients with bilateral, symptomatic peripheral arterial disease (PAD). PROCEDURES: Using a 1.5 Tesla MR scanner, 26 patients with bilateral symptomatic PAD and 24 healthy male controls underwent serial phosphorus-31 MR spectroscopy (31P MRS) during incremental exercise at 2, 3, 4, and 5 Watts. For each increment and recovery, PCr time constants, amplitudes of PCr changes and pH values were calculated from the MR spectra. In patients, the run-off resistance (ROR) was determined on MRA.
resultsThe patients exhibited significantly (p <or= 0.002) increased PCr time constants at the first (36.7, 13.8-360.3 vs. 22.9, 9.2-60.7 s), at the second (68.1, 4.2-757.2 vs. 18.3, 5.2-57.6 s), at the third (65.3, 14.7-277.7 vs. 29.0, 4.48-97.2 s), the fourth increment (64.1, 34.2-548.8 vs. 34.6, 4.9-106.2 s), and during recovery (53.2, 11.1-353.2 vs. 41.4, 15.1-122.4 s) compared to the normal controls. The PCr on-kinetics during the increments correlated significantly with the pH levels (r= -0.39 to -0.66, p <or= 0.005) at the end of the corresponding increments, but not with the RORs.
conclusionsThe correlation between PCr on-kinetics and end-increment pH values might indicate remodelling processes within the muscle that probably affect mitochondrial performance, diffusion of oxygen, and muscle fiber distribution. These parameters could be improved by exercise training.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.