ArticlePloS one2007
NF-kappaB/Rel-mediated regulation of the neural fate in Drosophila.
Article in PloS one, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Naturally Occurring Variability in the Regulatory Region of theInternational journal of molecular sciences · 2026Article
- Chronic bacterial infections exert metabolic costs in Drosophila melanogaster.The Journal of experimental biology · 2025Article
- The Drosophila tumor necrosis factor Eiger promotes Myc supercompetition independent of canonical Jun N-terminal kinase signaling.Genetics · 2024Article
- Differences in the Expression of TLR-2, NOD2, and NF-κB in Placenta Between Twins.Archivum immunologiae et therapiae experimentalis · 2018Article
- The Toll Pathway in the Central Nervous System of Flies and Mammals.Neuromolecular medicine · 2018Review
- Lateral inhibition: Two modes of non-autonomous negative autoregulation by neuralized.PLoS genetics · 2018Article
- Epstein-Barr Virus DNA Enhances Diptericin Expression and Increases Hemocyte Numbers inFrontiers in microbiology · 2018Article
- A systems level approach to temporal expression dynamics in Drosophila reveals clusters of long term memory genes.PLoS genetics · 2017Article
- The achaete-scute complex in Diptera: patterns of noncoding sequence evolution.Journal of evolutionary biology · 2015Article
- Retrograde neurotrophin signaling through Tollo regulates synaptic growth in Drosophila.The Journal of cell biology · 2014Article
- Conventional and non-conventional Drosophila Toll signaling.Developmental and comparative immunology · 2014Review
- NFκB signaling regulates embryonic and adult neurogenesis.Frontiers in biology · 2012Article
- The MYST-containing protein Chameau is required for proper sensory organ specification during Drosophila thorax morphogenesis.PloS one · 2012Article
- The kinase Sgg modulates temporal development of macrochaetes in Drosophila by phosphorylation of Scute and Pannier.Development (Cambridge, England) · 2012Article
- Toll-8/Tollo negatively regulates antimicrobial response in the Drosophila respiratory epithelium.PLoS pathogens · 2011Article
- Evolution and comparative genomics of subcellular specializations: EST sequencing of Torpedo electric organ.Marine genomics · 2011Article
- An arthropod cis-regulatory element functioning in sensory organ precursor development dates back to the Cambrian.BMC biology · 2010Article
- Genome-wide identification of cis-regulatory motifs and modules underlying gene coregulation using statistics and phylogeny.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Heterodimers of NF-kappaB transcription factors DIF and Relish regulate antimicrobial peptide genes in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Dorsal interacting protein 3 potentiates activation by Drosophila Rel homology domain proteins.Developmental and comparative immunology · 2008Article
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7 authors.
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Abstract
Two distinct roles are described for Dorsal, Dif and Relish, the three NF-kappaB/Rel proteins of Drosophila, in the development of the peripheral nervous system. First, these factors regulate transcription of scute during the singling out of sensory organ precursors from clusters of cells expressing the proneural genes achaete and scute. This effect is possibly mediated through binding sites for NF-kappaB/Rel proteins in a regulatory module of the scute gene required for maintenance of scute expression in precursors as well as repression in cells surrounding precursors. Second, genetic evidence suggests that the receptor Toll-8, Relish, Dif and Dorsal, and the caspase Dredd pathway are active over the entire imaginal disc epithelium, but Toll-8 expression is excluded from sensory organ precursors. Relish promotes rapid turnover of transcripts of the target genes scute and asense through an indirect, post-transcriptional mechanism. We propose that this buffering of gene expression levels serves to keep the neuro-epithelium constantly poised for neurogenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.