SynthesisBritish journal of cancer2007
Follow-up in breast cancer: does routine clinical examination improve outcome? A systematic review of the literature.
Synthesis in British journal of cancer, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07572370 (Evaluating the De-Escalation of Surveillance for Patients Who Have Undergone Curative Treatment for Primary Breast Cancer - A Prospective, Randomised Controlled Trial), which is not on this map. Cited by 46 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluating the De-Escalation of Surveillance for Patients Who Have Undergone Curative Treatment for Primary Breast Cancer - A Prospective, Randomised Controlled Trial
Who cites it
46 citing papers in PubMed, 5 syntheses or guidelines pooled it, 134 citations in OpenAlex.
- The COVID-19 pandemic: An opportunity to rethink and harmonise the frequency of follow-up visits for patients with early stage breast cancer.Cancer treatment reviews · 2021Pooled it
- Intensive follow-up for women with breast cancer: review of clinical, economic and patient's preference domains through evidence to decision framework.Health and quality of life outcomes · 2017Pooled it
- Pooled it
- Breast cancer follow-up strategies in randomized phase III adjuvant clinical trials: a systematic review.Journal of experimental & clinical cancer research : CR · 2013Pooled it
- Options for early breast cancer follow-up in primary and secondary care - a systematic review.BMC cancer · 2012Pooled it
- A Randomized Trial Evaluating Personalized Versus Guideline-Based Well Follow-Up Strategies for Patients with Early Breast Cancer: Feasibility Outcomes.Current oncology (Toronto, Ont.) · 2026Trial
- Patient satisfaction with nurse-led telephone follow-up after curative treatment for breast cancer.BMC cancer · 2010Trial
- ASO Author Reflections: Reexamining Physical Examination in Modern Breast Cancer Survivorship.Annals of surgical oncology · 2026Article
- Reassessing the Role of Regular Physical Examination in Post-treatment Breast Cancer Surveillance.Annals of surgical oncology · 2026Article
- Evaluating double-reading mammography for long-term surveillance in breast cancer survivors: a retrospective exploratory analysis from a single center.La Radiologia medica · 2026Article
- Surveillance mammography in older women-should we press on?Journal of the National Cancer Institute · 2026Article
- Breast cancer recurrence in relation to mode of detection: implications on personalized surveillance.Breast cancer research and treatment · 2025Article
- Developing machine learning models for personalized treatment strategies in early breast cancer patients undergoing neoadjuvant systemic therapy based on SEER database.Scientific reports · 2024Article
- A Clinical Analysis of Prognosis and Patient-Reported Outcomes of Oncoplastic Breast-Conserving Surgery for Early Breast Cancer: A Retrospective Cohort Study.Aesthetic plastic surgery · 2024Article
- Delayed diagnosis and increased mortality risk: Assessing the effects of the COVID-19 pandemic on breast cancer recurrence.Clinics (Sao Paulo, Brazil) · 2024Article
- Assessing Mode of Recurrence in Breast Cancer to Identify an Optimised Follow-Up Pathway: 10-Year Institutional Review.Annals of surgical oncology · 2023Review
- Regularly scheduled physical examinations and the detection of breast cancer recurrences.Breast (Edinburgh, Scotland) · 2023Article
- Adherence to the Dutch Breast Cancer Guidelines for Surveillance in Breast Cancer Survivors: Real-World Data from a Pooled Multicenter Analysis.The oncologist · 2022Article
- The effectiveness of mammography surveillance after treatment of primary breast cancer: A single centre retrospective cohort study.Annals of medicine and surgery (2012) · 2021Article
- A Pilot Trial Using Telemedicine in Radiation Oncology: The Future of Health Care Is Virtual.Telemedicine reports · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multiple guidelines exist for the follow-up of breast cancer, with no agreement on frequency or duration. The contribution of routine clinical examination for the detection of potentially treatable relapse, and the impact this has on survival, is unknown. In this study, we systematically review the literature to establish the proportion of potentially treatable locoregional relapses and new contralateral breast cancers detected by clinical examination, mammography and patient self-examination. We analyse whether method of detection of relapse influences outcome. The methods used were systematic review of the literature. MEDLINE, EMBASE, CancerLit, Web of Sciences and EBM reviews were the data sources for the systematic review. All studies with information on proportion of relapses detected by clinical examination, mammography and self-examination were included. A total of 30-40% of potentially treatable relapses are detected by patient self-examination. In studies published before 2000, 15% of such relapse is mammographically detected with 46% detected by routine clinical examination. In those published after 2000, 40% are mammographically detected with 15% detected on routine clinical examination. Patients with ipsilateral breast relapse detected clinically appear to do less well than those with relapse detected by self-examination or mammography. Routine clinical surveillance is responsible for detection of fewer potentially treatable relapses in more modern cohorts as experience with mammography increases. There is no evidence to suggest that clinical examination confers a survival advantage compared with other methods of detection. The data in this analysis suggest that a review of the guidelines on follow-up after breast cancer should be undertaken.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.