ArticleProceedings of the National Academy of Sciences of the United States of America2007
Natural stimuli evoke dynamic sequences of states in sensory cortical ensembles.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 155 papers.
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155 citing papers in PubMed.
- Locus coeruleus activation transforms cortical taste representations.Cell reports · 2026Article
- Sharp and smooth state transitions during resting state brain dynamics.bioRxiv : the preprint server for biology · 2026Article
- Signaling of salience and prediction errors by anterior insula neurons.Biochemical and biophysical research communications · 2026Article
- Article
- Drifting population dynamics with transient resets characterize sensorimotor transformation in the monkey superior colliculus.Communications biology · 2026Article
- Linear and categorical coding units in the mouse gustatory cortex drive population dynamics and behavior in taste decision-making.bioRxiv : the preprint server for biology · 2025Article
- The medial prefrontal cortex encodes procedural rules as sequential neuronal activity dynamics.Molecular brain · 2025Article
- Intermingled representation of oral cavity in mouse trigeminal ganglion.Scientific reports · 2025Article
- A sticky Poisson Hidden Markov Model for solving the problem of over-segmentation and rapid state switching in cortical datasets.bioRxiv : the preprint server for biology · 2025Article
- Development of brain metastable dynamics during the equivalent of the third gestational trimester.Developmental cognitive neuroscience · 2025Review
- Differential brainstem connectivity according to sex and menopausal status in healthy male and female individuals.Biology of sex differences · 2025Article
- Deficits in taste-guided behaviors and central processing of taste in the transgenic TDP-43Neurobiology of disease · 2025Article
- Metastability demystified - the foundational past, the pragmatic present and the promising future.Nature reviews. Neuroscience · 2025Review
- Cortex-wide spatiotemporal motifs of theta oscillations are coupled to freely moving behavior.Frontiers in systems neuroscience · 2025Article
- Background optic flow modulates responses of multiple descending interneurons to object motion in locusts.PloS one · 2025Article
- A sticky Poisson Hidden Markov Model for solving the problem of over-segmentation and rapid state switching in cortical datasets.PloS one · 2025Article
- Co-existence of synaptic plasticity and metastable dynamics in a spiking model of cortical circuits.PLoS computational biology · 2024Article
- Co-existence of synaptic plasticity and metastable dynamics in a spiking model of cortical circuits.bioRxiv : the preprint server for biology · 2024Article
- Multisensory Integration Underlies the Distinct Representation of Odor-Taste Mixtures in the Gustatory Cortex of Behaving Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Learning enhances representations of taste-guided decisions in the mouse gustatory insular cortex.Current biology : CB · 2024Article
95 more citing papers are in PubMed but not listed here.
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5 authors.
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Abstract
Although temporal coding is a frequent topic of neurophysiology research, trial-to-trial variability in temporal codes is typically dismissed as noise and thought to play no role in sensory function. Here, we show that much of this supposed "noise" faithfully reflects stimulus-related processes carried out in coherent neural networks. Cortical neurons responded to sensory stimuli by progressing through sequences of states, identifiable only in examinations of simultaneously recorded ensembles. The specific times at which ensembles transitioned from state to state varied from trial to trial, but the state sequences were reliable and stimulus-specific. Thus, the characterization of ensemble responses in terms of state sequences captured facets of sensory processing that are missing from, and obscured in, other analyses. This work provides evidence that sensory neurons act as parts of a systems-level dynamic process, the nature of which can best be appreciated through observation of distributed ensembles.
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