ArticleCurrent infectious disease reports2007
New insights on the pathogenesis of invasive Cryptococcus neoformans infection.
Article in Current infectious disease reports, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 64 citations in OpenAlex.
- Roles of Different Signaling Pathways inJournal of fungi (Basel, Switzerland) · 2024Review
- Unmasking the Unusual: Cryptococcal Pericarditis in a Patient with Liver Failure - a Rare Occurrence.The American journal of case reports · 2024Article
- Illuminating the Cryptococcus neoformans species complex: unveiling intracellular structures with fluorescent-protein-based markers.Genetics · 2024Article
- Two Methods of Measuring Cryptococcus neoformans Fungal Burden in Macrophages.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Antifungal activity of 6-substituted amiloride and hexamethylene amiloride (HMA) analogs.Frontiers in cellular and infection microbiology · 2023Article
- Article
- Pleural involvement in cryptococcal infection.World journal of clinical cases · 2022Article
- Cholesterol and sphingomyelin are critical for Fcγ receptor-mediated phagocytosis of Cryptococcus neoformans by macrophages.The Journal of biological chemistry · 2021Article
- Reimagining the future of African brain health: Perspectives for basic research on the pathogenesis of cryptococcal meningitis.Brain, behavior, & immunity - health · 2021Article
- Variations in the Community Structure of Fungal Microbiota Associated with Apple Fruit Shaped by Fruit Bagging-Based Practice.Journal of fungi (Basel, Switzerland) · 2021Article
- Incorporation of 2-amino-thiophene derivative in nanoparticles: enhancement of antifungal activity.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2020Article
- Cysteinyl leukotrienes as novel host factors facilitating Cryptococcus neoformans penetration into the brain.Cellular microbiology · 2017Article
- Diagnostic Challenges of Cryptococcus neoformans in an Immunocompetent Individual Masquerading as Chronic Hydrocephalus.Case reports in neurological medicine · 2016Article
- Increasing trend of fluconazole-non-susceptible Cryptococcus neoformans in patients with invasive cryptococcosis: a 12-year longitudinal study.BMC infectious diseases · 2015Article
- Article
- Cryptococcus neoformans: historical curiosity to modern pathogen.Yeast (Chichester, England) · 2014Review
- Factors required for activation of urease as a virulence determinant in Cryptococcus neoformans.mBio · 2013Article
- Capsule independent uptake of the fungal pathogen Cryptococcus neoformans into brain microvascular endothelial cells.PloS one · 2012Article
- Genome-wide expression profiling of the response to short-term exposure to fluconazole in Cryptococcus neoformans serotype A.BMC microbiology · 2011Article
- The RGS protein Crg2 is required for establishment and progression of murine pulmonary cryptococcosis.Medical mycology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Disseminated cryptococcosis begins with infection of the lungs via inhalation. This is followed by escape from the lungs and entry into the bloodstream allowing dissemination to the brain and central nervous system. We discuss the steps involved in dissemination and the host and microbial factors that influence each step. For the host, containment in the lung is accomplished with a combination of cell-mediated and antibody responses. Dissemination occurs when these systems fail and/or when phagocytic cells that fail to kill the yeast instead act as a niche for replication. One of the main microbial factors affecting dissemination is the polysaccharide capsule, a major virulence factor that promotes dissemination at every step. Secreted enzymes are important, including laccase and phospholipase B, which promote escape from the lungs, and urease, which contributes to crossing the blood-brain barrier. Lastly, a number of regulatory factors contribute, especially to growth of Cryptococcus neoformans in the brain.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.