ArticleGenome biology2007
Spore germination in Saccharomyces cerevisiae: global gene expression patterns and cell cycle landmarks.
Article in Genome biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 69 citations in OpenAlex.
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- Meiotic Cytokinesis inJournal of fungi (Basel, Switzerland) · 2024Review
- Triosephosphate Isomerase and Its Product Glyceraldehyde-3-Phosphate Are Involved in the Regulatory Mechanism That Suppresses Exit from the Quiescent State in Yeast Cells.Microbiology spectrum · 2022Article
- Post-Transcriptional Control of Mating-Type Gene Expression during Gametogenesis inBiomolecules · 2021Article
- TORC1 regulates the transcriptional response to glucose and developmental cycle via the Tap42-Sit4-Rrd1/2 pathway in Saccharomyces cerevisiae.BMC biology · 2021Article
- Saccharomyces spores are born prepolarized to outgrow away from spore-spore connections and penetrate the ascus wall.Yeast (Chichester, England) · 2021Article
- Dormancy-to-death transition in yeast spores occurs due to gradual loss of gene-expressing ability.Molecular systems biology · 2020Article
- Masters of asymmetry - lessons and perspectives from 50 years of septins.Molecular biology of the cell · 2020Review
- Sporulation inJournal of fungi (Basel, Switzerland) · 2020Review
- Spore Germination as a Target for Antifungal Therapeutics.Antimicrobial agents and chemotherapy · 2019Article
- Classification of Widely and Rarely Expressed Genes with Recurrent Neural Network.Computational and structural biotechnology journal · 2019Article
- Comparative Transcriptomics Reveals Features and Possible Mechanisms of Glucose-Mediated Soil Fungistasis Relief inFrontiers in microbiology · 2019Article
- Mating in wild yeast: delayed interest in sex after spore germination.Molecular biology of the cell · 2018Article
- Sporulation: how to survive on planet Earth (and beyond).Current genetics · 2017Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundSpore germination in the yeast Saccharomyces cerevisiae is a process in which non-dividing haploid spores re-enter the mitotic cell cycle and resume vegetative growth. To study the signals and pathways underlying spore germination we examined the global changes in gene expression and followed cell-cycle and germination markers during this process.
resultsWe find that the germination process can be divided into two distinct stages. During the first stage, the induced spores respond only to glucose. The transcription program during this stage recapitulates the general transcription response of yeast cells to glucose. Only during the second phase are the cells able to sense and respond to other nutritional components in the environment. Components of the mitotic machinery are involved in spore germination but in a distinct pattern. In contrast to the mitotic cell cycle, growth-related events during germination are not coordinated with nuclear events and are separately regulated. Thus, genes that are co-induced during G1/S of the mitotic cell cycle, the dynamics of the septin Cdc10 and the kinetics of accumulation of the cyclin Clb2 all exhibit distinct patterns of regulation during spore germination, which allow the separation of cell growth from nuclear events.
conclusionTaken together, genome-wide expression profiling enables us to follow the progression of spore germination, thus dividing this process into two major stages, and to identify germination-specific regulation of components of the mitotic cell cycle machinery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.