ReviewTheoretical biology & medical modelling2007
Inflammation: a way to understanding the evolution of portal hypertension.
Review in Theoretical biology & medical modelling, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 65 citations in OpenAlex.
- Recent Approaches in Portal Hypertension Involving Risk Stratification and Medical Management.Gastroenterology & hepatology · 2023Article
- Synergistic antioxidant and anti-inflammatory action of N-acetylcysteine in portal hypertensive gastropathy in rats.Hepatology forum · 2022Article
- Lymphatic dysfunction in advanced cirrhosis: Contextual perspective and clinical implications.World journal of hepatology · 2021Review
- IL-6-driven FasL promotes NF-κBp65/PUMA-mediated apoptosis in portal hypertensive gastropathy.Cell death & disease · 2019Article
- The Lymphatic Headmaster of the Mast Cell-Related Splanchnic Inflammation in Portal Hypertension.Cells · 2019Review
- The Usefulness of New-Generation Capsule Endoscopy in Patients with Portal Hypertensive Enteropathy.Clinical endoscopy · 2018Article
- Embrionary way to create a fatty liver in portal hypertension.World journal of gastrointestinal pathophysiology · 2017Review
- Capsule Endoscopy for Portal Hypertensive Enteropathy.Gastroenterology research and practice · 2016Review
- Aquaporin-1 is associated with arterial capillary proliferation and hepatic sinusoidal transformation contributing to portal hypertension in primary biliary cirrhosis.Medical molecular morphology · 2014Article
- Portal hypertension as immune mediate disease.Hepatitis monthly · 2014Review
- The effects of hyperammonemia in learning and brain metabolic activity.Metabolic brain disease · 2014Article
- Splanchnic-aortic inflammatory axis in experimental portal hypertension.World journal of gastroenterology · 2013Review
- A half century (1961-2011) of applying microsurgery to experimental liver research.World journal of hepatology · 2012Article
- Gut-brain chemokine changes in portal hypertensive rats.Digestive diseases and sciences · 2011Article
- The interstitial lymphatic peritoneal mesothelium axis in portal hypertensive ascites: when in danger, go back to the sea.International journal of inflammation · 2010Article
- Pathological axes of wound repair: gastrulation revisited.Theoretical biology & medical modelling · 2010Article
- A review of metabolic staging in severely injured patients.Scandinavian journal of trauma, resuscitation and emergency medicine · 2010Review
- Body composition changes after transjugular intrahepatic portosystemic shunt in patients with cirrhosis.World journal of gastroenterology · 2010Article
- Experimental obstructive cholestasis: the wound-like inflammatory liver response.Fibrogenesis & tissue repair · 2008Article
- The mast cell integrates the splanchnic and systemic inflammatory response in portal hypertension.Journal of translational medicine · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPortal hypertension is a clinical syndrome that manifests as ascites, portosystemic encephalopathy and variceal hemorrhage, and these alterations often lead to death. HYPOTHESIS: Splanchnic and/or systemic responses to portal hypertension could have pathophysiological mechanisms similar to those involved in the post-traumatic inflammatory response.The splanchnic and systemic impairments produced throughout the evolution of experimental prehepatic portal hypertension could be considered to have an inflammatory origin. In portal vein ligated rats, portal hypertensive enteropathy, hepatic steatosis and portal hypertensive encephalopathy show phenotypes during their development that can be considered inflammatory, such as: ischemia-reperfusion (vasodilatory response), infiltration by inflammatory cells (mast cells) and bacteria (intestinal translocation of endotoxins and bacteria) and lastly, angiogenesis. Similar inflammatory phenotypes, worsened by chronic liver disease (with anti-oxidant and anti-enzymatic ability reduction) characterize the evolution of portal hypertension and its complications (hepatorenal syndrome, ascites and esophageal variceal hemorrhage) in humans.
conclusionLow-grade inflammation, related to prehepatic portal hypertension, switches to high-grade inflammation with the development of severe and life-threatening complications when associated with chronic liver disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.