ArticleJournal of mammary gland biology and neoplasia2007
Molecular determinants of milk lipid secretion.
Article in Journal of mammary gland biology and neoplasia, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 106 citations in OpenAlex.
- Revealing gene expression links between milk fat globules and mammary glands in rodents via transcriptomics.Frontiers in veterinary science · 2025Article
- Structure, Biological Functions, Separation, Properties, and Potential Applications of Milk Fat Globule Membrane (MFGM): A Review.Nutrients · 2024Review
- Review: genetic background of milk fatty acid synthesis in bovines.Tropical animal health and production · 2023Review
- Intra- and Interspecies RNA-Seq Based Variants in the Lactation Process of Ruminants.Animals : an open access journal from MDPI · 2022Article
- LPIN1 promotes triglycerides synthesis and is transcriptionally regulated by PPARG in buffalo mammary epithelial cells.Scientific reports · 2022Article
- Occludin is a target of Src kinase and promotes lipid secretion by binding to BTN1a1 and XOR.PLoS biology · 2022Article
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- TDP-43 facilitates milk lipid secretion by post-transcriptional regulation of Btn1a1 and Xdh.Nature communications · 2020Article
- Knockout of butyrophilin subfamily 1 member A1 (Journal of animal science and biotechnology · 2020Article
- Role of Phospholipid Flux during Milk Secretion in the Mammary Gland.Journal of mammary gland biology and neoplasia · 2017Review
- Kinetics of milk lipid droplet transport, growth, and secretion revealed by intravital imaging: lipid droplet release is intermittently stimulated by oxytocin.Molecular biology of the cell · 2017Article
- Variant discovery in the sheep milk transcriptome using RNA sequencing.BMC genomics · 2017Article
- Isolation of Endoplasmic Reticulum Fractions from Mammary Epithelial Tissue.Journal of mammary gland biology and neoplasia · 2016Article
- MicroRNA-26a/b and their host genes synergistically regulate triacylglycerol synthesis by targeting the INSIG1 gene.RNA biology · 2016Article
- Indirect Immunofluorescence on Frozen Sections of Mouse Mammary Gland.Journal of visualized experiments : JoVE · 2015Article
- Evaluation of inhibition of F4ac positive Escherichia coli attachment with xanthine dehydrogenase, butyrophilin, lactadherin and fatty acid binding protein.BMC veterinary research · 2015Article
- Identification of Escherichia coli F4ac-binding proteins in porcine milk fat globule membrane.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2015Article
- Lipid transport in the lactating mammary gland.Journal of mammary gland biology and neoplasia · 2014Review
- Underlying mechanisms involved in the decrease of milk secretion during Escherichia coli endotoxin induced mastitis in lactating mice.Veterinary research · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
Mammary epithelial cells secrete lipids by an envelopment process that produces lipid droplets coated by membranes derived from the plasma membrane and possibly secretory vesicles. This secretion process, which resembles viral budding, is hypothesized to be mediated by specific interactions between molecules on the surface of intracellular lipids and membrane elements of the cell. Multiple lines of evidence indicate that milk lipid secretion occurs through a tripartite complex between the integral transmembrane protein, butyrophilin (BTN); the soluble metabolic enzyme, xanthine oxidoreductase (XOR); and the lipid droplet surface protein, adipophilin (ADPH). However, topological evidence from freeze-fracture replica immunolabelling (FRIL) challenge this model and suggests that milk lipid secretion is mediated by butyrophilin alone. Advances in our understanding of the molecular, structural, and functional properties of these proteins now make it possible to understand the physiological functions of each of these molecules in detail and to identify the specific molecular determinants that mediate milk lipid secretion.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.