ReviewDevelopment genes and evolution2007
Regenerating the central nervous system: how easy for planarians!
Review in Development genes and evolution, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
69 citing papers in PubMed.
- Ephrin Signaling Patterns Sensory Neurons During Tissue Homeostasis in Planarians.bioRxiv : the preprint server for biology · 2026Article
- Timing of exposure impacts how organophosphorus pesticides affect the developing brain in the planarian Dugesia japonica.Archives of toxicology · 2026Article
- Deciphering the ancestral mechanisms of neural regeneration through single-cell analyses of jellyfish rhopalium repair.Science advances · 2026Article
- Verification of quantum biological predictions for weak magnetic field effects on superoxide in planarians.PNAS nexus · 2026Article
- SoxB1-mediated chromatin remodeling promotes sensory neuron differentiation in planarians.Genetics · 2026Article
- SoxB1-Mediated Chromatin Remodeling Promotes Sensory Neuron Differentiation in Planarians.bioRxiv : the preprint server for biology · 2025Article
- Red Midge Larvae Are an Invertebrate Alternative Diet to Beef Liver for Planarian Husbandry.Biomolecules · 2025Article
- Article
- Regeneration in planarians modifies behavioral switching.iScience · 2025Article
- Neuropeptide-mediated temporal sensory filtering in a primordial nervous system.bioRxiv : the preprint server for biology · 2024Article
- Verification of radical pair mechanism predictions for weak magnetic field effects on superoxide in planarians.bioRxiv : the preprint server for biology · 2024Article
- Terminal differentiation precedes functional circuit integration in the peduncle neurons in regenerating Hydra vulgaris.Neural development · 2024Article
- Schild Analysis of the Interaction between Parthenolide and Cocaine Suggests an Allosteric Relationship for Their Effects on Planarian Motility.Biomolecules · 2024Article
- Adaptive robustness through incoherent signaling mechanisms in a regenerative brain.Cell reports · 2024Article
- A wound-induced differentiation trajectory for neurons.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- How neurobehavior and brain development in alternative whole-organism models can contribute to prediction of developmental neurotoxicity.Neurotoxicology · 2024Review
- Collective intelligence: A unifying concept for integrating biology across scales and substrates.Communications biology · 2024Review
- MRLC controls apoptotic cell death and functions to regulate epidermal development during planarian regeneration and homeostasis.Cell proliferation · 2024Article
- LIM-HD transcription factors control axial patterning and specify distinct neuronal and intestinal cell identities in planarians.Open biology · 2023Article
- Genetic factors in methylmercury-induced neurotoxicity: What have we learned fromAdvances in neurotoxicology · 2023Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The regenerative capabilities of freshwater planarians (Platyhelminthes) are very difficult to match. A fragment as tiny as 1/279th of the planarian body is able to regenerate a whole animal within very few days [Morgan. Arch Entwm 7:364-397 (1898)]. Although the planarian central nervous system (CNS) may appear quite morphologically simple, recent studies have shown it to be more complex at the molecular level, revealing a high degree of molecular compartmentalization in planarian cephalic ganglia. Planarian neural genes include homologues of well-known transcription factors and genes involved in human diseases, neurotransmission, axon guidance, signaling pathways, and RNA metabolism. The availability of hundreds of genes expressed in planarian neurons coupled with the ability to silence them through the use of RNA interference makes it possible to start unraveling the molecular mechanisms underlying CNS regeneration. In this review, I discuss current knowledge on the planarian nervous system and the genes involved in its regeneration, and I discuss some of the important questions that remain to be answered.
Indexed as
Identifiers
17999079What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.