ArticlePlanta2008
Virus-induced silencing of Comt, pAmt and Kas genes results in a reduction of capsaicinoid accumulation in chili pepper fruits.
Article in Planta, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Comparative genome-wide identification and analysis of the COMT gene family in potato (Solanum tuberosum L.) and Arabidopsis ( Arabidopsis thaliana (L.) Heynh.).BMC plant biology · 2026Article
- Laminar patterning transcription factors orchestrate spatial metabolite partitioning in Capsicum fruit.Nature plants · 2026Article
- Spicy genes: mapping quantitative genomic regions and candidate genes for capsaicinoid and capsinoid biosynthesis in pepper.Frontiers in plant science · 2026Review
- Virus-Induced Genome Editing (VIGE): One Step Away from an Agricultural Revolution.International journal of molecular sciences · 2025Review
- The transcriptional analysis of pepper shed light on a proviral role of light-harvesting chlorophyll a/b binding protein 13 during infection of pepper mild mottle virus.Frontiers in plant science · 2025Article
- SynGAP: a synteny-based toolkit for gene structure annotation polishing.Genome biology · 2024Article
- Functional characterization ofBiochemistry and biophysics reports · 2024Article
- Development of a 45K pepper GBTS liquid-phase gene chip and its application in genome-wide association studies.Frontiers in plant science · 2024Article
- MYB24 Negatively Regulates the Biosynthesis of Lignin and Capsaicin by Affecting the Expression of Key Genes in the Phenylpropanoid Metabolism Pathway inMolecules (Basel, Switzerland) · 2023Article
- Geminivirus-Derived Vectors as Tools for Functional Genomics.Frontiers in microbiology · 2022Review
- Ethylene-Inducible AP2/ERF Transcription Factor Involved in the Capsaicinoid Biosynthesis inFrontiers in plant science · 2022Article
- Genetic mapping revealed that theFrontiers in plant science · 2022Article
- Capsaicinoid biosynthesis in the pericarp of chili pepper fruits is associated with a placental septum-like transcriptome profile and tissue structure.Plant cell reports · 2021Article
- The pungent-variable sweet chili pepper 'Shishito' (Capsicum annuum) provides insights regarding the relationship between pungency, the number of seeds, and gene expression involving capsaicinoid biosynthesis.Molecular genetics and genomics : MGG · 2021Article
- Transcriptomic analysis of a wild and a cultivated varieties of Capsicum annuum over fruit development and ripening.PloS one · 2021Article
- Coexpression network analysis reveals an MYB transcriptional activator involved in capsaicinoid biosynthesis in hot peppers.Horticulture research · 2020Article
- Biochemistry and molecular biology of capsaicinoid biosynthesis: recent advances and perspectives.Plant cell reports · 2019Review
- Discovery of novel unfunctionalBreeding science · 2019Article
- Mutation in the putative ketoacyl-ACP reductase CaKR1 induces loss of pungency in Capsicum.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2019Article
- Effect of foliar application of salicylic acid, hydrogen peroxide and a xyloglucan oligosaccharide on capsiate content and gene expression associatedwith capsinoids synthesis in Capsicum annuum L.Journal of biosciences · 2017Article
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Authors and funding
5 authors.
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Abstract
Capsaicinoids are responsible for the pungent taste of chili pepper fruits of Capsicum species. Capsaicinoids are biosynthesized through both the phenylpropanoid and the branched-fatty acids pathways. Fragments of Comt (encoding a caffeic acid O-methyltransferase), pAmt (a putative aminotransferase), and Kas (a beta-keto-acyl-[acyl-carrier-protein] synthase) genes, that are differentially expressed in placenta tissue of pungent chili pepper, were individually inserted into a Pepper huasteco yellow veins virus (PHYVV)-derived vector to determine, by virus-induced gene silencing, irrespective of whether these genes are involved in the biosynthesis of capsaicinoids. Reduction of the respective mRNA levels as well as the presence of related siRNAs confirmed the silencing of these three genes. Morphological alterations were evident in plants inoculated with PHYVV::Comt and PHYVV::Kas constructs; however, plants inoculated with PHYVV::pAmt showed no evident alterations. On the other hand, fruit setting was normal in all cases. Biochemical analysis of placenta tissues showed that, indeed, independent silencing of all three genes led to a dramatic reduction in capsaicinoid content in the fruits demonstrating the participation of these genes in capsaicinoid biosynthesis. Using this approach it was possible to generate non-pungent chili peppers at high efficiency.
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