ArticleThe Journal of cell biology2007
A genome-wide RNAi screen reveals multiple regulators of caspase activation.
Article in The Journal of cell biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 84 citations in OpenAlex.
- Predicting leaf nitrogen content in wolfberry trees by hyperspectral transformation and machine learning for precision agriculture.PloS one · 2024Article
- Naa10p and IKKα interaction regulates EMT in oral squamous cell carcinoma via TGF-β1/Smad pathway.Journal of cellular and molecular medicine · 2021Article
- Proteomic Analysis of Red Ginseng on Prolonging the Life Span of MaleFrontiers in pharmacology · 2021Article
- Overlap of NatA and IAP substrates implicates N-terminal acetylation in protein stabilization.Science advances · 2021Article
- Structure and Mechanism of Acetylation by the N-Terminal Dual Enzyme NatA/Naa50 Complex.Structure (London, England : 1993) · 2019Article
- ARD1 contributes to IKKβ-mediated breast cancer tumorigenesis.Cell death & disease · 2018Article
- A Cell-based Assay to Investigate Non-muscle Myosin II Contractility via the Folded-gastrulation Signaling Pathway in Drosophila S2R+ Cells.Journal of visualized experiments : JoVE · 2018Article
- Versatility of ARD1/NAA10-mediated protein lysine acetylation.Experimental & molecular medicine · 2018Review
- ARD1/NAA10 in hepatocellular carcinoma: pathways and clinical implications.Experimental & molecular medicine · 2018Review
- RNA Interference (RNAi) Screening inGenetics · 2018Article
- Proteomic and genomic characterization of a yeast model for Ogden syndrome.Yeast (Chichester, England) · 2017Article
- ARD1-mediated Hsp70 acetylation balances stress-induced protein refolding and degradation.Nature communications · 2016Article
- Ligand stimulation of CD95 induces activation of Plk3 followed by phosphorylation of caspase-8.Cell research · 2016Article
- Review
- Sphingolipids as cell fate regulators in lung development and disease.Apoptosis : an international journal on programmed cell death · 2015Review
- A systems-level interrogation identifies regulators of Drosophila blood cell number and survival.PLoS genetics · 2015Article
- Cell biology. Metabolic control of cell death.Science (New York, N.Y.) · 2014Review
- Inverse correlation between Naa10p and MMP-9 expression and the combined prognostic value in breast cancer patients.Medical oncology (Northwood, London, England) · 2013Article
- High-throughput RNA interference screens integrative analysis: Towards a comprehensive understanding of the virus-host interplay.World journal of virology · 2013Review
- Protein N-terminal acetyltransferases in cancer.Oncogene · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Apoptosis is an evolutionally conserved cellular suicide mechanism that can be activated in response to a variety of stressful stimuli. Increasing evidence suggests that apoptotic regulation relies on specialized cell death signaling pathways and also integrates diverse signals from additional regulatory circuits, including those of cellular homeostasis. We present a genome-wide RNA interference screen to systematically identify regulators of apoptosis induced by DNA damage in Drosophila melanogaster cells. We identify 47 double- stranded RNA that target a functionally diverse set of genes, including several with a known function in promoting cell death. Further characterization uncovers 10 genes that influence caspase activation upon the removal of Drosophila inhibitor of apoptosis 1. This set includes the Drosophila initiator caspase Dronc and, surprisingly, several metabolic regulators, a candidate tumor suppressor, Charlatan, and an N-acetyltransferase, ARD1. Importantly, several of these genes show functional conservation in regulating apoptosis in mammalian cells. Our data suggest a previously unappreciated fundamental connection between various cellular processes and caspase-dependent cell death.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.