ArticleInfection and immunity2008
Temporal regulation of interleukin-12p70 (IL-12p70) and IL-12-related cytokines in splenic dendritic cell subsets during Leishmania donovani infection.
Article in Infection and immunity, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 37 citations in OpenAlex.
- Commensal bacteria promote type I interferon signaling to maintain immune tolerance in mice.The Journal of experimental medicine · 2024Article
- Leishmaniasis: Immune Cells Crosstalk in Macrophage Polarization.Tropical medicine and infectious disease · 2023Review
- Determinants of Innate Immunity in Visceral Leishmaniasis and Their Implication in Vaccine Development.Frontiers in immunology · 2021Review
- Role of Cytokines in Experimental and Human Visceral Leishmaniasis.Frontiers in cellular and infection microbiology · 2021Review
- IL-27 signalling regulates glycolysis in Th1 cells to limit immunopathology during infection.PLoS pathogens · 2020Article
- Type I Interferons Suppress Anti-parasitic Immunity and Can Be Targeted to Improve Treatment of Visceral Leishmaniasis.Cell reports · 2020Article
- Interleukin-27 Functional Duality BalancesFrontiers in immunology · 2020Review
- Regulation of immunity during visceral Leishmania infection.Parasites & vectors · 2016Review
- Interleukin-27 Early ImpactsFrontiers in immunology · 2016Article
- Experimental models to investigate the function of dendritic cell subsets: challenges and implications.Clinical and experimental immunology · 2013Review
- Natural killer cells in experimental and human leishmaniasis.Frontiers in cellular and infection microbiology · 2012Review
- Amniotic fluid and amniotic membrane stem cells: marker discovery.Stem cells international · 2012Article
- Article
- IL-10-producing Th1 cells and disease progression are regulated by distinct CD11c⁺ cell populations during visceral leishmaniasis.PLoS pathogens · 2012Article
- Stromal cell induction of regulatory dendritic cells.Frontiers in immunology · 2012Article
- Critical role of IRF-5 in the development of T helper 1 responses to Leishmania donovani infection.PLoS pathogens · 2011Article
- Spleen-resident CD4+ and CD4- CD8α- dendritic cell subsets differ in their ability to prime invariant natural killer T lymphocytes.PloS one · 2011Article
- Immune evasion by Yersinia enterocolitica: differential targeting of dendritic cell subpopulations in vivo.PLoS pathogens · 2010Article
- Imaging of the host/parasite interplay in cutaneous leishmaniasis.Experimental parasitology · 2010Review
- Immune evasive mechanisms contributing to persistent Leishmania donovani infection.Immunologic research · 2010Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Dendritic cells (DC) play an essential role in initiating and directing T-cell responses, in part by production of interleukin-12p70 (IL-12p70), IL-23, and IL-27. However, comparative studies on the capacity for cytokine production of DC subsets are rare. Here, we compare splenic CD8alpha+, CD4+, and double-negative (DN) DC, isolated 5 h to 28 days after Leishmania donovani infection, for (i) production of IL-12p70, (ii) accumulation of IL-12/23p40, IL-12p35, IL-23p19, and IL-27p28 mRNAs, and (iii) their capacity to direct CD4+ T-cell differentiation. At 5 h, conventional DC (cDC) accumulated mRNA for IL-12/23p40 (CD8alpha>CD4>DN), IL-23p19 (CD4>CD8alpha>DN), and IL-27p28 (CD8alpha>CD4>DN), in an infection dose-dependent manner. IL-12p70 was restricted to CD8alpha+ cDC, reflecting the subset-specific accumulation of IL-12p35 mRNA. In contrast, cDC from mice infected for 14 to 28 days accumulated little mRNA for IL-12p40 and IL-12p19, though IL-27p28 mRNA remained detectable (CD8alpha>DN>CD4). IL-12p70 secretion by CD8alpha+ cDC was also absent, reflecting deficient IL-12/23p40, rather than IL-12p35, mRNA accumulation. The capacity of CD8alpha+ cDC isolated early after infection to direct Th1 cell differentiation was mediated through IL-12/23p40, whereas this ability in CD4+ and DN cDC was independent of IL-12/23p40 and did not result from overexpression of Delta 4 Notch-like ligand. However, DN cDC produced gamma interferon (IFN-gamma) and also contained a rare population of CD11c(hi) DX5+ IFN-gamma-producing cells. Our data illustrate the extensive diversity in, and temporal regulation of, splenic cDC subsets during infection and suggest caution in interpreting data obtained with unfractionated or minimally purified DC.
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