ArticleBMC genomics2007
Lactation transcriptomics in the Australian marsupial, Macropus eugenii: transcript sequencing and quantification.
Article in BMC genomics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 62 citations in OpenAlex.
- β-Lactoglobulin and Glycodelin: Two Sides of the Same Coin?Frontiers in physiology · 2021Review
- Article
- Didelphis albiventris: an overview of unprecedented transcriptome sequencing of the white-eared opossum.BMC genomics · 2019Article
- The tammar wallaby: A marsupial model to examine the timed delivery and role of bioactives in milk.General and comparative endocrinology · 2017Review
- Antimicrobial Protection of Marsupial Pouch Young.Frontiers in microbiology · 2017Review
- Characterisation of the immune compounds in koala milk using a combined transcriptomic and proteomic approach.Scientific reports · 2016Article
- The identification of immune genes in the milk transcriptome of the Tasmanian devil (Sarcophilus harrisii).PeerJ · 2016Article
- A novel highly divergent protein family identified from a viviparous insect by RNA-seq analysis: a potential target for tsetse fly-specific abortifacients.PLoS genetics · 2014Article
- Amelioration of reproduction-associated oxidative stress in a viviparous insect is critical to prevent reproductive senescence.PloS one · 2014Article
- Monotremes and marsupials: comparative models to better understand the function of milk.Journal of biosciences · 2012Article
- The mammary gland-specific marsupial ELP and eutherian CTI share a common ancestral gene.BMC evolutionary biology · 2012Article
- Review
- Genome sequence of an Australian kangaroo, Macropus eugenii, provides insight into the evolution of mammalian reproduction and development.Genome biology · 2011Article
- A novel approach identified the FOLR1 gene, a putative regulator of milk protein synthesis.Mammalian genome : official journal of the International Mammalian Genome Society · 2009Article
- Identification and transcript analysis of a novel wallaby (Macropus eugenii) basal-like breast cancer cell line.Molecular cancer · 2008Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLactation is an important aspect of mammalian biology and, amongst mammals, marsupials show one of the most complex lactation cycles. Marsupials, such as the tammar wallaby (Macropus eugenii) give birth to a relatively immature newborn and progressive changes in milk composition and milk production regulate early stage development of the young.
resultsIn order to investigate gene expression in the marsupial mammary gland during lactation, a comprehensive set of cDNA libraries was derived from lactating tissues throughout the lactation cycle of the tammar wallaby. A total of 14,837 express sequence tags were produced by cDNA sequencing. Sequence analysis and sequence assembly were used to construct a comprehensive catalogue of mammary transcripts. Sequence data from pregnant and early or late lactating specific cDNA libraries and, data from early or late lactation massively parallel sequencing strategies were combined to analyse the variation of milk protein gene expression during the lactation cycle.
conclusionResults show a steady increase in expression of genes coding for secreted protein during the lactation cycle that is associated with high proportion of transcripts coding for milk proteins. In addition, genes involved in immune function, translation and energy or anabolic metabolism are expressed across the lactation cycle. A number of potential new milk proteins or mammary gland remodelling markers, including noncoding RNAs have been identified.
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