ArticleBehavioral and brain functions : BBF2007
Transgenic mice expressing constitutive active MAPKAPK5 display gender-dependent differences in exploration and activity.
Article in Behavioral and brain functions : BBF, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 30 citations in OpenAlex.
- A methylation study of long-term depression risk.Molecular psychiatry · 2020Article
- Comparative molecular dynamics simulations of mitogen-activated protein kinase-activated protein kinase 5.International journal of molecular sciences · 2014Article
- Homology modeling and ligand docking of Mitogen-activated protein kinase-activated protein kinase 5 (MK5).Theoretical biology & medical modelling · 2013Article
- MK5 activates Rag transcription via Foxo1 in developing B cells.The Journal of experimental medicine · 2013Article
- Norepinephrine transporter variant A457P knock-in mice display key features of human postural orthostatic tachycardia syndrome.Disease models & mechanisms · 2013Article
- Tumour promoting and suppressing roles of the atypical MAP kinase signalling pathway ERK3/4-MK5.Journal of molecular signaling · 2012Article
- The extracellular signal-regulated kinase 3 (mitogen-activated protein kinase 6 [MAPK6])-MAPK-activated protein kinase 5 signaling complex regulates septin function and dendrite morphology.Molecular and cellular biology · 2012Article
- Septin 8 is an interaction partner and in vitro substrate of MK5.World journal of biological chemistry · 2012Article
- Physiological roles of mitogen-activated-protein-kinase-activated p38-regulated/activated protein kinase.World journal of biological chemistry · 2011Article
- Serine residue 115 of MAPK-activated protein kinase MK5 is crucial for its PKA-regulated nuclear export and biological function.Cellular and molecular life sciences : CMLS · 2011Article
- The diterpenoid alkaloid noroxoaconitine is a Mapkap kinase 5 (MK5/PRAK) inhibitor.Cellular and molecular life sciences : CMLS · 2011Article
- Affect-related behaviors in mice misexpressing the RNA editing enzyme ADAR2.Physiology & behavior · 2009Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe mitogen-activated protein kinases, MAPKs for short, constitute cascades of signalling pathways involved in the regulation of several cellular processes that include cell proliferation, differentiation and motility. They also intervene in neurological processes like fear conditioning and memory. Since little remains known about the MAPK-Activated Protein Kinase, MAPKAPK5, we constructed the first MAPKAPK knockin mouse model, using a constitutive active variant of MAPKAPK5 and analyzed the resulting mice for changes in anxiety-related behaviour.
methodsWe performed primary SHIRPA observations during background breeding into the C57BL/6 background and assessed the behaviour of the background-bred animals on the elevated plus maze and in the light-dark test. Our results were analyzed using Chi-square tests and homo- and heteroscedatic T-tests.
resultsFemale transgenic mice displayed increased amounts of head dips and open arm time on the maze, compared to littermate controls. In addition, they also explored further into the open arm on the elevated plus maze and were less active in the closed arm compared to littermate controls. Male transgenic mice displayed no differences in anxiety, but their locomotor activity increased compared to non-transgenic littermates.
conclusionOur results revealed anxiety-related traits and locomotor differences between transgenic mice expressing constitutive active MAPKAPK5 and control littermates.
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