ArticlePLoS computational biology2007
A dynamical systems hypothesis of schizophrenia.
Article in PLoS computational biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
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71 citing papers in PubMed, 169 citations in OpenAlex.
- Mental training enhances attentional stability: neural and behavioral evidence.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Trial
- Dynamical system modeling in schizophrenia: a narrative review of computational psychiatry frameworks.Dialogues in clinical neuroscience · 2026Review
- Depression: higher temporal variability of the functional connectivity of the ventromedial prefrontal cortex and hippocampal system.NeuroImage. Clinical · 2026Article
- The extracellular matrix as a dynamic regulator of brain function and plasticity.Neurobiology of disease · 2026Review
- Association-sensory spatiotemporal hierarchy and functional gradient-regularised recurrent neural network with implications for schizophrenia.NPJ systems biology and applications · 2026Article
- From microstates to macroscales: A Critical Review of Maximum Entropy Modeling and Energy Landscape Analysis in functional MRI.Research square · 2025Article
- Learning evoked centrality dynamics in the schizophrenia brain: entropy, heterogeneity, and inflexibility of brain networks.Journal of psychiatry & neuroscience : JPN · 2025Article
- Higher dopamine D1 receptor expression in prefrontal parvalbumin neurons underlies higher distractibility in marmosets versus macaques.Communications biology · 2025Article
- Network state dynamics underpin basal craving in a transdiagnostic population.Molecular psychiatry · 2025Article
- Effect of High-voltage Electrical Field Exposure on Neurobiological Factors and Visual Working Memory of Macaques.Basic and clinical neuroscience · 2025Article
- Revisiting the role of computational neuroimaging in the era of integrative neuroscience.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- A biophysical model for dopamine modulating working memory through reward system in obsessive-compulsive disorder.Cognitive neurodynamics · 2024Article
- Article
- Effects of long-term antipsychotic medication on brain instability in first-episode schizophrenia patients: a resting-state fMRI study.Frontiers in pharmacology · 2024Article
- Fractal basins as a mechanism for the nimble brain.Scientific reports · 2023Article
- Network state dynamics underpin craving in a transdiagnostic population.medRxiv : the preprint server for health sciences · 2023Article
- Theory-Driven Analysis of Natural Language Processing Measures of Thought Disorder Using Generative Language Modeling.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023Article
- Dysconnectivity in Schizophrenia Revisited: Abnormal Temporal Organization of Dynamic Functional Connectivity in Patients With a First Episode of Psychosis.Schizophrenia bulletin · 2023Article
- Spike timing-dependent plasticity under imbalanced excitation and inhibition reduces the complexity of neural activity.Frontiers in computational neuroscience · 2023Article
- Context-independent expression of spatial code in hippocampus.Scientific reports · 2022Article
11 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We propose a top-down approach to the symptoms of schizophrenia based on a statistical dynamical framework. We show that a reduced depth in the basins of attraction of cortical attractor states destabilizes the activity at the network level due to the constant statistical fluctuations caused by the stochastic spiking of neurons. In integrate-and-fire network simulations, a decrease in the NMDA receptor conductances, which reduces the depth of the attractor basins, decreases the stability of short-term memory states and increases distractibility. The cognitive symptoms of schizophrenia such as distractibility, working memory deficits, or poor attention could be caused by this instability of attractor states in prefrontal cortical networks. Lower firing rates are also produced, and in the orbitofrontal and anterior cingulate cortex could account for the negative symptoms, including a reduction of emotions. Decreasing the GABA as well as the NMDA conductances produces not only switches between the attractor states, but also jumps from spontaneous activity into one of the attractors. We relate this to the positive symptoms of schizophrenia, including delusions, paranoia, and hallucinations, which may arise because the basins of attraction are shallow and there is instability in temporal lobe semantic memory networks, leading thoughts to move too freely round the attractor energy landscape.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.