ArticlePLoS computational biology2007
Are there rearrangement hotspots in the human genome?
Article in PLoS computational biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Random, fragile, or correlated: Mechanisms of synteny decay in mammals.bioRxiv : the preprint server for biology · 2025Article
- Genes that are Used Together are More Likely to be Fused Together in Evolution by Mutational Mechanisms: A Bioinformatic Test of the Used-Fused Hypothesis.Evolutionary biology · 2023Article
- Large Drosophila germline piRNA clusters are evolutionarily labile and dispensable for transposon regulation.Molecular cell · 2021Article
- On the rank-distance median of 3 permutations.BMC bioinformatics · 2018Article
- Breaking Good: Accounting for Fragility of Genomic Regions in Rearrangement Distance Estimation.Genome biology and evolution · 2016Article
- A high-density linkage map enables a second-generation collared flycatcher genome assembly and reveals the patterns of avian recombination rate variation and chromosomal evolution.Molecular ecology · 2014Article
- The elusive evidence for chromothripsis.Nucleic acids research · 2014Article
- Phylogenetic analysis of genome rearrangements among five mammalian orders.Molecular phylogenetics and evolution · 2012Article
- Annotation of the domestic dog genome sequence: finding the missing genes.Mammalian genome : official journal of the International Mammalian Genome Society · 2012Article
- On pairwise distances and median score of three genomes under DCJ.BMC bioinformatics · 2012Article
- The rise and fall of breakpoint reuse depending on genome resolution.BMC bioinformatics · 2011Article
- Anchoring the dog to its relatives reveals new evolutionary breakpoints across 11 species of the Canidae and provides new clues for the role of B chromosomes.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2011Article
- Comparative analysis of DNA replication timing reveals conserved large-scale chromosomal architecture.PLoS genetics · 2010Article
- Comparative genomics reveals birth and death of fragile regions in mammalian evolution.Genome biology · 2010Article
- Analysis of fine-scale mammalian evolutionary breakpoints provides new insight into their relation to genome organisation.BMC genomics · 2009Article
- Gene synteny comparisons between different vertebrates provide new insights into breakage and fusion events during mammalian karyotype evolution.BMC evolutionary biology · 2009Article
- Revisiting the missing protein-coding gene catalog of the domestic dog.BMC genomics · 2009Article
- The infinite sites model of genome evolution.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Addressing chromosome evolution in the whole-genome sequence era.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2008Review
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2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
In a landmark paper, Nadeau and Taylor [18] formulated the random breakage model (RBM) of chromosome evolution that postulates that there are no rearrangement hotspots in the human genome. In the next two decades, numerous studies with progressively increasing levels of resolution made RBM the de facto theory of chromosome evolution. Despite the fact that RBM had prophetic prediction power, it was recently refuted by Pevzner and Tesler [4], who introduced the fragile breakage model (FBM), postulating that the human genome is a mosaic of solid regions (with low propensity for rearrangements) and fragile regions (rearrangement hotspots). However, the rebuttal of RBM caused a controversy and led to a split among researchers studying genome evolution. In particular, it remains unclear whether some complex rearrangements (e.g., transpositions) can create an appearance of rearrangement hotspots. We contribute to the ongoing debate by analyzing multi-break rearrangements that break a genome into multiple fragments and further glue them together in a new order. In particular, we demonstrate that (1) even if transpositions were a dominant force in mammalian evolution, the arguments in favor of FBM still stand, and (2) the "gene deletion" argument against FBM is flawed.
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