ArticleCurrent biology : CB2007
The genetic basis of inbreeding avoidance in house mice.
Article in Current biology : CB, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
82 citing papers in PubMed, 179 citations in OpenAlex.
- Male and female mice scent mark during social communication regardless of sexual motivation or partner identity.Cell reports · 2026Article
- Kin recognition for incest avoidance in Damaraland mole-rats,Proceedings. Biological sciences · 2024Article
- Female behavior drives the formation of distinct social structures in C57BL/6J versus wild-derived outbred mice in field enclosures.BMC biology · 2024Article
- Re-wilding model organisms: Opportunities to test causal mechanisms in social determinants of health and aging.Neuroscience and biobehavioral reviews · 2023Review
- Exosome-guided direct reprogramming of tumor-associated macrophages from protumorigenic to antitumorigenic to fight cancer.Bioactive materials · 2023Article
- Dynamic changes to signal allocation rules in response to variable social environments in house mice.Communications biology · 2023Article
- Effect of MHC and inbreeding on disassortative reproduction: A data revisit, extension and inclusion of fertilization in sand lizards.Ecology and evolution · 2023Article
- Population structure and inbreeding in wild house mice (Mus musculus) at different geographic scales.Heredity · 2022Article
- Regulation of Sexually Dimorphic Expression of Major Urinary Proteins.Frontiers in physiology · 2022Review
- Lymphocytic Choriomeningitis Virus Alters the Expression of Male Mouse Scent Proteins.Viruses · 2021Article
- Infection threat shapes our social instincts.Behavioral ecology and sociobiology · 2021Review
- Maternally inherited peptides as strain-specific chemosignals.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- First experimental evidence for olfactory species discrimination in two nocturnal primate species (Microcebus lehilahytsara and M. murinus).Scientific reports · 2019Article
- Mouse protein coding diversity: What's left to discover?PLoS genetics · 2019Review
- Molecular complexity of the major urinary protein system of the Norway rat, Rattus norvegicus.Scientific reports · 2019Article
- Drivers of sex ratio bias in the eastern bongo: lower inbreeding increases the probability of being born male.Proceedings. Biological sciences · 2019Article
- Update on the human and mouse lipocalin (LCN) gene family, including evidence the mouse Mup cluster is result of an "evolutionary bloom".Human genomics · 2019Review
- Regulation of volatile and non-volatile pheromone attractants depends upon male social status.Scientific reports · 2019Article
- Effects of point mutations in the binding pocket of the mouse major urinary protein MUP20 on ligand affinity and specificity.Scientific reports · 2019Article
- No evidence for kin protection in the expression of sickness behaviors in house mice.Scientific reports · 2018Article
22 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Animals might be able to use highly polymorphic genetic markers to recognize very close relatives and avoid inbreeding. The major histocompatibility complex (MHC) is thought to provide such a marker because it influences individual scent in a broad range of vertebrates. However, direct evidence is very limited. In house mice (Mus musculus domesticus), the major urinary protein (MUP) gene cluster provides another highly polymorphic scent signal of genetic identity that could underlie kin recognition. We demonstrate that wild mice breeding freely in seminatural enclosures show no avoidance of mates with the same MHC genotype when genome-wide similarity is controlled. Instead, inbreeding avoidance is fully explained by a strong deficit in successful matings between mice sharing both MUP haplotypes. Single haplotype sharing is not a good guide to the identification of full sibs, and there was no evidence of behavioral imprinting on maternal MHC or MUP haplotypes. This study, the first to examine wild animals with normal variation in MHC, MUP, and genetic background, demonstrates that mice use self-referent matching of a species-specific polymorphic signal to avoid inbreeding. Recognition of close kin as unsuitable mates might be more variable across species than a generic vertebrate-wide ability to avoid inbreeding based on MHC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.