ArticleInternational immunopharmacology2007
Immunomodulatory activity of acidic polysaccharides isolated from Tanacetum vulgare L.
Article in International immunopharmacology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 109 citations in OpenAlex.
- Pooled it
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- Immune-Stimulatory Effects of Althaea rosea Flower Extracts through the MAPK Signaling Pathway in RAW264.7 Cells.Molecules (Basel, Switzerland) · 2017Article
- Anvillea garcinii extract inhibits the oxidative burst of primary human neutrophils.BMC complementary and alternative medicine · 2016Article
- A metabonomic investigation on the biochemical perturbation in post-stroke patients with depressive disorder (PSD).Metabolic brain disease · 2016Article
- Immuno-stimulatory activity of a polysaccharide-enriched fraction of Sutherlandia frutescens occurs by the toll-like receptor-4 signaling pathway.Journal of ethnopharmacology · 2015Article
- Herbal medicine IMOD suppresses LPS-induced production of proinflammatory cytokines in human dendritic cells.Frontiers in pharmacology · 2015Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Tanacetum vulgare L. (Tansy) has been extensively used in folk medicine for treatment of a variety of medical disorders. In the present study, we isolated and purified four acidic polysaccharide fractions (designated T-I to T-IV) from Tansy florets by the sequential use of hot-water extraction, ethanol precipitation, ultra-filtration, anion-exchange, and size-exclusion chromatography. The average M(r) of fractions T-I through T-IV was estimated to be 326, 151, 64 and 9 kDa, respectively, as determined by high performance size-exclusion chromatography analysis. Sugar composition analysis revealed that Tansy polysaccharides consisted primarily of galacturonic acid, galactose, arabinose, and rhamnose. Fractions T-II through T-IV contained an arabinogalactan type II structure, as determined by reaction with Yariv reagent. High M(r) fractions T-I and T-II exhibited potent macrophage/monocyte-activating activity, enhancing production of reactive oxygen species (ROS), nitric oxide (NO), and tumor necrosis factor alpha (TNF-alpha) by J774.A1 murine macrophages, and activating nuclear factor kappaB (NF-kappaB) in THP-1 human monocytes. In addition, Tansy polysaccharides stimulated human neutrophil function by greatly enhancing neutrophil myeloperoxidase (MPO) release. Furthermore, the low M(r) fraction T-IV had potent complement-fixing activity, which may also contribute to the anti-inflammatory and would-healing properties of Tansy extracts. Taken together, our results provide a molecular basis to explain at least part of the beneficial therapeutic effects of Tansy extracts, and support the concept of using Tansy polysaccharides as an immunotherapeutic adjuvant.
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Registered trials
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