ArticleCancer cell2007
In situ carcinoma - can we predict which patient will come back with a recurrence?
Article in Cancer cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 6 citations in OpenAlex.
- Review
- Article
- Subtype-Specific Tumour Immune Microenvironment in Risk of Recurrence of Ductal Carcinoma In Situ: Prognostic Value of HER2.Biomedicines · 2022Review
- Presence of an in situ component is associated with reduced biological aggressiveness of size-matched invasive breast cancer.British journal of cancer · 2010Article
- Occurrence of cancer at multiple sites: towards distinguishing multigenesis from metastasis.Biology direct · 2008Review
- Repositioning chloroquine and metformin to eliminate cancer stem cell traits in pre-malignant lesions.Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapyArticle
Corrections and comments
- Comment on
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The frequency of in situ carcinomas has been rising since the introduction of mammographic screening. The management of patients with preinvasive disease remains difficult due to our lack of ability to accurately predict which patients will recur and progress to invasive carcinoma. Although some factors, such as lesion size and extent of margin clearance, are strong predictors of recurrence, many patients are still under- or overtreated. In this issue of Cancer Cell, Gauthier and colleagues suggest that abrogated response to cell stress measured by analysis of p16 and the proliferation marker Ki67 accurately predicts recurrence in ductal carcinoma in situ.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.