ArticleCancer cell2007
Nucleosomes at active promoters: unforgettable loss.
Article in Cancer cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- Epigenetic regulation of MAGE family in human cancer progression-DNA methylation, histone modification, and non-coding RNAs.Clinical epigenetics · 2018Review
- The landscape of RNA polymerase II transcription initiation in C. elegans reveals promoter and enhancer architectures.Genome research · 2013Article
- DNA methylation and nucleosome occupancy regulate the cancer germline antigen gene MAGEA11.Epigenetics · 2013Article
- CpG island hypermethylation-associated silencing of non-coding RNAs transcribed from ultraconserved regions in human cancer.Oncogene · 2010Article
- Identification and characterization of putative methylation targets in the MAOA locus using bioinformatic approaches.Epigenetics · 2010Article
- Article
- Characterizing nucleosome dynamics from genomic and epigenetic information using rule induction learning.BMC genomics · 2009Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A variety of chromatin features have been implicated in the regulation of gene expression, including nucleosome occupancy at promoters, histone modifications and variants, and DNA methylation. In this issue of Cancer Cell, Lin and colleagues use a powerful single-molecule approach to explore the relationship between nucleosome occupancy and gene expression in cancer cells. They show that nucleosome occupancy is mostly all-or-none at the multiple start sites of the MLH1 CpG island. After demethylation by drug treatment, nucleosomes are permanently lost as transcription becomes reactivated. Thus, epigenetic maintenance of gene expression may require that promoters are maintained free of nucleosomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.