ArticleNeuroscience2007
Regulation of netrin-1 receptors by amphetamine in the adult brain.
Article in Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- Identification of candidate genes associated with bipolar disorder by whole-exome sequencing of a Chinese multi-affected pedigree.BMC psychiatry · 2025Article
- Rewiring the future: drugs abused in adolescence may predispose to mental illness in adult life by altering dopamine axon growth.Journal of neural transmission (Vienna, Austria : 1996) · 2024Review
- Reduced dopamine release in Dcc haploinsufficiency male mice abolishes the rewarding effects of cocaine but not those of morphine and ethanol.Psychopharmacology · 2023Article
- Mesocorticolimbic Dopamine Pathways Across Adolescence: Diversity in Development.Frontiers in neural circuits · 2021Review
- Early Adolescence is a Critical Period for the Maturation of Inhibitory Behavior.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Mesocorticolimbic Connectivity and Volumetric Alterations inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Article
- Amphetamine in adolescence disrupts the development of medial prefrontal cortex dopamine connectivity in a DCC-dependent manner.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- The Netrin-1 receptor DCC is a regulator of maladaptive responses to chronic morphine administration.BMC genomics · 2014Article
- Adolescence: a time of transition for the phenotype of dcc heterozygous mice.Psychopharmacology · 2014Article
- Growth factors in synaptic function.Frontiers in synaptic neuroscience · 2013Review
- Dopaminergic axon guidance: which makes what?Frontiers in cellular neuroscience · 2012Article
- Expression and function of dopamine receptors in the developing medial frontal cortex and striatum of the rat.Neuroscience · 2011Article
- AAV-mediated netrin-1 overexpression increases peri-infarct blood vessel density and improves motor function recovery after experimental stroke.Neurobiology of disease · 2011Article
- Abolition of the behavioral phenotype of adult netrin-1 receptor deficient mice by exposure to amphetamine during the juvenile period.Psychopharmacology · 2011Article
- Binge cocaine administration in adolescent rats affects amygdalar gene expression patterns and alters anxiety-related behavior in adulthood.Biological psychiatry · 2011Article
- Role of netrin-1 in the organization and function of the mesocorticolimbic dopamine system.Journal of psychiatry & neuroscience : JPN · 2011Review
- The netrin receptor DCC is required in the pubertal organization of mesocortical dopamine circuitry.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Peri-pubertal emergence of UNC-5 homologue expression by dopamine neurons in rodents.PloS one · 2010Article
- Prenatal inflammation-induced hypoferremia alters dopamine function in the adult offspring in rat: relevance for schizophrenia.PloS one · 2010Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Netrin-1 is a guidance cue molecule fundamental to the organization of neuronal connectivity during development. Netrin-1 and its receptors, deleted in colorectal cancer (DCC) and UNC-5 homologues (UNC-5), continue to be expressed in the adult brain, although neither their function nor the kinds of events that activate their expression are known. Two lines of evidence suggest a role for netrin-1 in amphetamine-induced dopamine plasticity in the adult. First, DCC is highly expressed by adult dopamine neurons. Second, adult mice with reduced DCC levels do not develop amphetamine-induced behavioral sensitization. To explore the role of netrin-1 in amphetamine-induced plasticity, we examined the effects of sensitizing treatment regimens of amphetamine on DCC and/or UNC-5 protein expression in the adult rat. These treatments produced striking and enduring increases in DCC and UNC-5 expression in the cell body, but not terminal regions, of the mesocorticolimbic dopamine system. Notably, neuroadaptations in the cell body region of mesocorticolimbic dopamine neurons underlie the development of sensitization to the effects of amphetamine. Furthermore, these localized amphetamine-induced changes were prevented by co-treatment with an N-methyl-d-aspartate receptor antagonist, a treatment known to block the development of amphetamine-induced sensitization of behavioral activation, dopamine release and motivated behavior. Using immunohistochemistry, we showed that both DCC and UNC-5 receptors are highly expressed by adult mesocorticolimbic dopamine neurons. These results provide the first evidence that repeated exposure to a stimulant drug such as amphetamine affects netrin-1 receptor expression in the adult brain. Taken together, our findings suggest that changes in netrin-1 receptor expression may play a role in the lasting effects of exposure to amphetamine and other stimulant drugs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.