Trial reportBMC neurology2007
Protocol for the Locomotor Experience Applied Post-stroke (LEAPS) trial: a randomized controlled trial.
Trial report in BMC neurology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 6 registered trials, which are not on this map. Cited by 87 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Locomotor Experience Applied Post Stroke (LEAPS) Trial
Cardiovascular Function in Sub Maximal Exercise and Performance in Three Daily Activity Tests in Persons With Post Stroke Conditions
Multifactorial, Evidence-based Program of Screening, Risk Modification and Physical Therapy to Prevent Falls Among Vulnerable Elderly Recently Discharged From Hospital to the Community.
The Singapore Tele-technology Aided Rehabilitation in Stroke (STARS) Study: A Randomized Controlled Trial
GAIT Recovery in Patients aFter Acute Ischemic STroke: A Randomized Comparison of Robot-assisted and Therapist-assisted Gait Training on a Treadmill.
The Effect of Combined Transcranial Pulse Current Stimulation (tPCS) and Transcutaneous Electrical Nerve Stimulation (TENS) on Lower Limb Motor Function in Subacute to Chronic Stroke Patients With Hemiplegia: A Double-blind, Sham-controlled, Randomized Controlled Study
Who cites it
87 citing papers in PubMed, 7 syntheses or guidelines pooled it, 205 citations in OpenAlex.
- Predictive Value of Upper Extremity Outcome Measures After Stroke-A Systematic Review and Metaregression Analysis.Frontiers in neurology · 2021Pooled it
- Treadmill training and body weight support for walking after stroke.The Cochrane database of systematic reviews · 2017Pooled it
- Factors Influencing the Efficacy of Aerobic Exercise for Improving Fitness and Walking Capacity After Stroke: A Meta-Analysis With Meta-Regression.Archives of physical medicine and rehabilitation · 2017Pooled it
- Physical fitness training for stroke patients.The Cochrane database of systematic reviews · 2016Pooled it
- Treadmill training and body weight support for walking after stroke.The Cochrane database of systematic reviews · 2014Pooled it
- Wearable systems for monitoring mobility-related activities in chronic disease: a systematic review.Sensors (Basel, Switzerland) · 2010Pooled it
- Overground physical therapy gait training for chronic stroke patients with mobility deficits.The Cochrane database of systematic reviews · 2009Pooled it
- Role of Contralesional Corticoreticulospinal Tract Compensation in Walking Function After Stroke.Brain and behavior · 2026Trial
- Cardiopulmonary exercise tests in people with chronic stroke: Interpretation and clinical application.Clinical rehabilitation · 2025Trial
- Trial
- Trial
- Predictors of Daily Steps at 1-Year Poststroke: A Secondary Analysis of a Randomized Controlled Trial.Stroke · 2021Trial
- Effect of Outpatient Rehabilitation on Functional Mobility After Single Total Knee Arthroplasty: A Randomized Clinical Trial.JAMA network open · 2020Trial
- Effects of horse-riding therapy and rhythm and music-based therapy on functional mobility in late phase after stroke.NeuroRehabilitation · 2019Trial
- Trial
- Evaluating the effects of delivering integrated kinesthetic and tactile cues to individuals with unilateral hemiparetic stroke during overground walking.Journal of neuroengineering and rehabilitation · 2018Trial
- The role of movement errors in modifying spatiotemporal gait asymmetry post stroke: a randomized controlled trial.Clinical rehabilitation · 2018Trial
- Locomotor Training and Strength and Balance Exercises for Walking Recovery After Stroke: Response to Number of Training Sessions.Physical therapy · 2017Trial
- Guided Training Relative to Direct Skill Training for Individuals With Cognitive Impairments After Stroke: A Pilot Randomized Trial.Archives of physical medicine and rehabilitation · 2017Trial
- High-Intensity Interval Training and Moderate-Intensity Continuous Training in Ambulatory Chronic Stroke: Feasibility Study.Physical therapy · 2016Trial
27 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundLocomotor training using body weight support and a treadmill as a therapeutic modality for rehabilitation of walking post-stroke is being rapidly adopted into clinical practice. There is an urgent need for a well-designed trial to determine the effectiveness of this intervention. The objective of the Locomotor Experience Applied Post-Stroke (LEAPS) trial is to determine if there is a difference in the proportion of participants who recover walking ability at one year post-stroke when randomized to a specialized locomotor training program (LTP), conducted at 2- or 6-months post-stroke, or those randomized to a home based non-specific, low intensity exercise intervention (HEP) provided 2 months post-stroke. We will determine if the timing of LTP delivery affects gait speed at 1 year and whether initial impairment severity interacts with the timing of LTP. The effect of number of treatment sessions will be determined by changes in gait speed taken pre-treatment and post-12, -24, and -36 sessions. METHODS/
designWe will recruit 400 adults with moderate or severe walking limitations within 30 days of stroke onset. At two months post stroke, participants are stratified by locomotor impairment severity as determined by overground walking speed and randomly assigned to one of three groups: (a) LTP-Early; (b) LTP-Late or (c) Home Exercise Program -Early. The LTP program includes body weight support on a treadmill and overground training. The LTP and HEP interventions are delivered for 36 sessions over 12 weeks. Primary outcome measure include successful walking recovery defined as the achievement of a 0.4 m/s gait speed or greater by persons with initial severe gait impairment or the achievement of a 0.8 m/s gait speed or greater by persons with initial moderate gait impairment.LEAPS is powered to detect a 20% difference in the proportion of participants achieving successful locomotor recovery between the LTP groups and the HEP group, and a 0.1 m/s mean difference in gait speed change between the two LTP groups. DISCUSSION: The goal of this single-blinded, phase III randomized clinical trial is to provide evidence to guide post-stroke walking recovery programs.
trial registrationNCT00243919.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.