ArticleBMC medical genetics2007
Exploring the functional role of the CHRM2 gene in human cognition: results from a dense genotyping and brain expression study.
Article in BMC medical genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
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- TheApplied and environmental microbiology · 2024Article
- Normalization of impaired emotion inhibition in bipolar disorder mediated by cholinergic neurotransmission in the cingulate cortex.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Dynamic network impairments underlie cognitive fluctuations in Lewy body dementia.NPJ Parkinson's disease · 2022Article
- Promoting Immortalized Adipose-Derived Stem Cell Transdifferentiation and Proliferation into Neuronal-Like Cells through Consecutive 525 nm and 825 nm Photobiomodulation.Stem cells international · 2022Article
- Long-Term Effects of Ionizing Radiation on the Hippocampus: Linking Effects of the Sonic Hedgehog Pathway Activation with Radiation Response.International journal of molecular sciences · 2021Article
- Gene Expression Differences Between Young Adults Based on Trauma History and Post-traumatic Stress Disorder.Frontiers in psychiatry · 2021Article
- Dietary Oligofructose Alone or in Combination with 2'-Fucosyllactose Differentially Improves Recognition Memory and Hippocampal mRNA Expression.Nutrients · 2020Article
- GRM8 genotype is associated with externalizing disorders and greater inter-trial variability in brain activation during a response inhibition task.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2020Article
- A network pharmacology-based study on Alzheimer disease prevention and treatment of Qiong Yu Gao.BioData mining · 2020Article
- Genetic polymorphisms of CYP3A5, CHRM2, and ZNF498 and their association with epilepsy susceptibility: a pharmacogenetic and case-control study.Pharmacogenomics and personalized medicine · 2019Article
- Toward the Language Oscillogenome.Frontiers in psychology · 2018Article
- How neuroscience can inform the study of individual differences in cognitive abilities.Reviews in the neurosciences · 2017Review
- Article
- Conserved expression of transposon-derived non-coding transcripts in primate stem cells.BMC genomics · 2017Article
- Variants Near CCK Receptors are Associated With Electrophysiological Responses to Pre-pulse Startle Stimuli in a Mexican American Cohort.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2015Article
- Preliminary evidence for associations of CHRM2 with substance use and disinhibition in adolescence.Journal of abnormal child psychology · 2011Article
- Genetic variation in cholinergic muscarinic-2 receptor gene modulates M2 receptor binding in vivo and accounts for reduced binding in bipolar disorder.Molecular psychiatry · 2011Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
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Abstract
backgroundThe CHRM2 gene, located on the long arm of chromosome 7 (7q31-35), is involved in neuronal excitability, synaptic plasticity and feedback regulation of acetylcholine release, and has been implicated in higher cognitive processing. The aim of this study is the identification of functional (non)coding variants underlying cognitive phenotypic variation.
methodsWe previously reported an association between polymorphisms in the 5'UTR regions of the CHRM2 gene and intelligence.. However, no functional variants within this area have currently been identified. In order to identify the relevant functional variant(s), we conducted a denser coverage of SNPs, using two independent Dutch cohorts, consisting of a children's sample (N = 371 ss; mean age 12.4) and an adult sample (N= 391 ss; mean age 37.6). For all individuals standardized intelligence measures were available. Subsequently, we investigated genotype-dependent CHRM2 gene expression levels in the brain, to explore putative enhancer/inhibition activity exerted by variants within the muscarinic acetylcholinergic receptor.
resultsUsing a test of within-family association two of the previously reported variants - rs2061174, and rs324650 - were again strongly associated with intelligence (P < 0.01). A new SNP (rs2350780) showed a trend towards significance. SNP rs324650, is located within a short interspersed repeat (SINE). Although the function of short interspersed repeats remains contentious, recent research revealed potential functionality of SINE repeats in a gene-regulatory context. Gene-expression levels in post-mortem brain material, however were not dependent on rs324650 genotype.
conclusionUsing a denser coverage of SNPs in the CHRM2 gene, we confirmed the 5'UTR regions to be most interesting in the context of intelligence, and ruled out other regions of this gene. Although no correlation between genomic variants and gene expression was found, it would be interesting to examine allele-specific effects on CHRM2 transcripts expression in much more detail, for example in relation to transcripts specific halve-life and their relation to LTP and memory.
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