ArticleJournal of general internal medicine2008
Pseudohyponatremia in a patient with HIV and hepatitis C coinfection.
Article in Journal of general internal medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 17 citations in OpenAlex.
- Pseudohyponatremia Caused by Severe Hemolysis.Cureus · 2025Article
- Evidence-based hyponatremia management in liver disease.Clinical and molecular hepatology · 2023Review
- Pseudohyponatremia: Mechanism, Diagnosis, Clinical Associations and Management.Journal of clinical medicine · 2023Review
- Pseudohyponatraemia caused by acute pancreatitis-derived hypertriglyceridaemia.BMJ case reports · 2021Article
- Hyponatremia in kidney transplant patients: its pathophysiologic mechanisms.Clinical kidney journal · 2018Article
- Hyponatremia is a marker of disease severity in HIV-infected patients: a retrospective cohort study.BMC infectious diseases · 2017Article
- Hyponatremia in patients with liver diseases: not just a cirrhosis-induced hemodynamic compromise.Hepatology international · 2016Review
- Water, electrolytes, and acid-base alterations in human immunodeficiency virus infected patients.World journal of nephrology · 2016Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pseudohyponatremia refers to low serum sodium in the presence of normal plasma tonicity. Whereas pseudohyponatremia secondary to hyperlipidemia is a commonly recognized occurrence, falsely low sodium levels secondary to elevated protein are less frequently observed. We present in this paper the case of a man coinfected with HIV and hepatitis C who had pseudohyponatremia from hypergammaglobulinemia. As hypergammaglobulinemia is a frequent occurrence in both HIV and HCV, we suggest that pseudohyponatremia is an important and likely underdiagnosed phenomenon in this patient population. Clinicians need to be aware of the electrolyte exclusion effect and become familiar with the techniques used by their local laboratory in the measurement of serum electrolytes. Pseudohyponatremia should also be included in the differential diagnosis of an elevated osmolal gap, as the falsely lowered sodium level will lead to a falsely low calculated serum osmolality.
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